Sentences with phrase «by nonsense mutations»
«Our new data is scientifically important because ataluren restores activity to genes inactivated by nonsense mutations, and as a result, it has the potential to do so much for a large number of very complex genetic disorders,» Jacobson said.
https://www.sciencedaily.com/
In Irish Setters, rcd1 is caused by a nonsense mutation G > A transition at nucleotide position 2420 in PDEB gene.
Not exact matches
«Given this mechanism, ataluren offers the potential for a new therapeutic approach for multiple nonsense mutation genetic disorders by targeting the underlying cause of the disease.»
Ataluren and amlexanox, work by enabling cells to bypass a particular type of DNA gene change known as a nonsense mutation.
Most of the somatic mutations were missense mutations (n = 72), followed by nonsense (n = 10) and frameshift mutations (n = 9)(Figure 1B).