Sentences with phrase «by nucleosomes»
The ability of PARP1 to control cellular processes is regulated by nucleosomes — the basic unit of DNA packaging, consisting of a segment of DNA wound in sequence around eight histone protein cores, similar to a thread wrapped around a spool.
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Li M, Hada A, Sen P, Olufemi L, Hall MA, Smith BY, Forth S, McKnight JN, Patel A, Bowman GD, Bartholomew B, Wang MD. (2015) Dynamic regulation of transcription factors by nucleosome remodeling.
Not exact matches
«Our paper shows that suppressing ASF1 induces ALT by affecting nucleosome assembly,» he says.
Genomic DNA is packaged into nucleosomes, which are formed by histone proteins that have DNA wrapped around them.
Our genes are packaged into cells by wrapping them around protein structures called nucleosomes.
Made up of nucleosomes — roll - shaped bundles of DNA and protein — the heterochromatin is connected by a velcro - like feature called «Heterochromatin Protein 1 (HP1).»
In the new study, Tulin and his colleagues reevaluated how PARP1 is activated by changes in the nucleosome.
Since many of the genes containing «fragile» nucleosomes are controlled in a continuous manner by nutrient availability, modulation of promoter nucleosome stability may be a strategy used to coordinate growth - related transcription on a genome - wide level.
When a given gene needs to be transcribed to create new proteins, its promoter region must be unwrapped from the nucleosome so that it can be accessed by the factors involved in initiating the transcription process.
One type, characterized by the presence of dynamic, unstable, nucleosomes, is found at highly expressed genes, such as those involved in the control of cell growth and division.
«We have revealed the existence of two types of promoters, which differ by the presence of «fragile» nucleosomes,» says Slawomir Kubik, first author of the study and researcher at UNIGE.
Human cytomegalovirus major immediate early 1 protein targets host chromosomes by docking to the acidic pocket on the nucleosome surface.
The forward - and reverse - oriented peaks were usually separated by around 180 base pairs, and corresponded to nucleosome boundaries.
The evidence for this comes from observing 30 nm and 120 nm wide fibres formed by DNA and nucleosomes purified from cells.
BAZ2A is an essential component of the nucleolar remodeling complex (NoRC), which mediates recruitment of histone modifyine enzymes and DNA methylase involved in the silencing of ribosomal RNA transcription by RNA polymerase I. BAZ2B is believed to be involved in regulating nucleosome mobilization along linear DNA.
After DNA replication, nucleosome density is maintained by incorporating newly synthesized histones besides the recycling of parental histones (Figure 1).