Sentences with phrase «by other compounds»

However, this makes them vulnerable to damage by other compounds in the sample.

Because our cells are made up of mostly water, if we dehydrated them to the point of having no fluid, they would be damaged by so - called solution effects, which result from the cell being too concentrated and not having its water replaced by some other compound.

Coibamide A showed a pattern of activity unmatched by any other compound, suggesting it might be able to fight cancer through a mechanism of action unlike that of any existing drug.

Not exact matches

And these problems were compounded by the parallel objectives of some of the other leading European factions.

While most of us have an accountant, a lawyer, an insurance guy, an investment manager and other individual advisers, for the very rich these issues» complexity is compounded by the sheer amount of capital involved.

The oddity is compounded by the fact that, in recent years, the trappings of the disaster film have overtaken other genres as well.

Among the factors that could cause actual results to differ materially are the following: (1) worldwide economic, political, and capital markets conditions and other factors beyond the Company's control, including natural and other disasters or climate change affecting the operations of the Company or its customers and suppliers; (2) the Company's credit ratings and its cost of capital; (3) competitive conditions and customer preferences; (4) foreign currency exchange rates and fluctuations in those rates; (5) the timing and market acceptance of new product offerings; (6) the availability and cost of purchased components, compounds, raw materials and energy (including oil and natural gas and their derivatives) due to shortages, increased demand or supply interruptions (including those caused by natural and other disasters and other events); (7) the impact of acquisitions, strategic alliances, divestitures, and other unusual events resulting from portfolio management actions and other evolving business strategies, and possible organizational restructuring; (8) generating fewer productivity improvements than estimated; (9) unanticipated problems or delays with the phased implementation of a global enterprise resource planning (ERP) system, or security breaches and other disruptions to the Company's information technology infrastructure; (10) financial market risks that may affect the Company's funding obligations under defined benefit pension and postretirement plans; and (11) legal proceedings, including significant developments that could occur in the legal and regulatory proceedings described in the Company's Annual Report on Form 10 - K for the year ended Dec. 31, 2017, and any subsequent quarterly reports on Form 10 - Q (the «Reports»).

He would later learn that while the blast killed five bystanders and injured 17 others, his colleagues were protected by the Land Cruiser's armour plating and legged it back to Sallyport's compound safely.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Because China begins the process with the highest investment level in history, the extent of the transformation must exceed that of any other case, and it must occur at a time when weak Chinese demand is compounded by weak global demand, thereby reducing productive investment opportunities for the private sector.

Public Works and Government Services Canada has increased its spending on external «Other» professional services by 212 percent since 2006/07, equivalent to 18 percent compound annual growth — a total increase of $ 332 million per year.

All of this is further compounded by a dearth of blockchain - skilled talent, as well as the difficulty of incentivizing other projects, developers, and teams to build on top of your technology.

Whereas Leclerc argued that the ultimate constituents of material reality are mini-substances which act on each other reciprocally and by their interaction co-constitute the new reality of a compound substance (NPE, 309 - 10), Ford argues that such natural compounds are instead to be understood as «single strands of personally ordered actual occasions, potentially divisible into structured societies but not actually so divided» (109).

there is endless evidence via fossils and other remains of how certain cells evolved light sensitivity and spent billions of years evolving through simple compound eyes to what we see today; the myriad different eyes used by species that presently inhabit the earth.

Ivor Leclerc (3) has recently shown that although Whitehead has - done more than other atomists in explaining the kind of unity possessed by compounds and organisms, he still fails to do justice to the distinctive characteristics that emerge and function at these supraparticle levels.

With Leibniz, Hartshorne maintains that some organisms are governed by a «dominant entelechy» that serves as a center of perception and activity (Monadology # 70); other organisms, and all inorganic wholes (e.g. chemical compounds and minerals), have insufficient organizational complexity to act or feel «as one.

«The action of one compound «atom» on another is not, by the scientific evidence, an aggregate action of the electrons and protons individually on each other.

This style renders the book difficult to assess, and the difficulty is compounded by the frequently offered advice to consult the author's other writings for a fuller discussion.

This is compounded by the fact that most of the people who join in a young movement have come from other areas of the church and bring their baggage with them.

Consequently, one is left with no clear answer as to the order in which events present themselves to God, and the problem is compounded by the stipulation that each actual occasion prehends God and thus has access to his awareness of other actual occasions (God's «consequent nature»).

Therefore we can conclude that a greater quantity of phenolic compounds will be provided by consumption of steamed broccoli as compared with broccoli prepared by other cooking processes.

The researchers added: «Other bioactive compounds present in nuts, including micronutrients, fibre, and phytochemicals, may also contribute to their cardio - protective effect by reducing inflammation, improving vascular reactivity as well as fasting glucose and insulin sensitivity, and by lowering oxidative stress status.

Studies have shown that these cancer - fighting compounds and enzymes found in broccoli and other cruciferous vegetables may actually prevent the relapse of certain cancers by killing cancer stem cells.

This is due to the fact that shade - grown teas respond to sunlight by increase chlorophyll levels and other chemical compounds, including caffeine.

It is considered one of the most multi-dimensional foods in the world, containing complex sugars, live enzymes and other naturally occurring compounds and is consumed daily by many.

The most obvious incident was the clear pull back on Alexis Sanchez in the box which was not given and then compounded by giving Sunderland a penalty at the other end.

Like other bad services, I think this one may have been partly due to altitude, but he compounded this error by then committing a bad back pass.

While soy - based formulas are recommended by some health experts, others say that some compound such as amino acids are lacking in these formulas, which help a baby grow.

The impact of poverty is compounded by numerous other issues in a hostile asylum system, from the years spent living in dirty and poorly maintained asylum accommodation, to years of waiting in limbo in fear of being returned home whilst facing disbelief from Home Office officials.

Weak governance, gross insensitivity and unacceptable levels of incompetence have been compounded by battles of attrition in which northerners have sapped each other's» strength.

Already, there are reported cases of some foreign investors exiting our capital market, job losses which may further compound the high unemployment rate, the closure of public sector department in the banks, among other measures being adopted by the operators of the private sector to remain afloat.

(GlaxoSmithKline has decided to stop marketing ezogabine but other existing drugs that also operate by tweaking potassium channels in brain cells — or a wholly new class of compounds — could serve in its place.)

Typically, chemists make molecules by mixing up many constituent atoms, some of which stick to each other to form the desired compounds.

But unlike those and other detection schemes, Mirkin and colleagues say, the new approach should make it possible to detect many different target compounds simply by altering the sensing molecule.

And, notes Richard Denison, senior scientist at Environmental Defense Fund, many other PFC compounds not covered by the EPA actions or voluntary phaseouts are currently used — including in food packaging — that raise similar environmental health concerns.

Some compounds could be identified by comparing their profiles with a database of molecules from other conifer tree species, although most compounds could not be identified.

By looking at how the chemicals there react with each other at very high pressures and low temperatures, they were able to predict which compounds are formed in the mantle.

Careful analysis of what frequencies are absorbed, and by how much, can directly reveal the presence of water vapor and other compounds, and can divulge climate parameters, such as temperature and pressure, that determine if liquid water is sustainable.

Turning over rocks across the crater, the rover has compiled evidence of ancient water — a lake fed by rivers once occupied the crater itself — and organic compounds and other chemicals essential for life.

A final series of tests confirmed that toxic compounds generated by antibodies kill bacteria without any help from other immune cells, like macrophages.

Compounding the problem is that minority scientists are often compelled — by their own conscience, surely, but also by colleagues and administrators — to be mentors for other minority undergraduate and graduate students, Jackson says.

The UCLA researchers, led by David Eisenberg, director of the UCLA - Department of Energy Institute of Genomics and Proteomics and a Howard Hughes Medical Institute investigator, report the first application of this technique in the search for molecular compounds that bind to and inhibit the activity of the amyloid - beta protein responsible for forming dangerous plaques in the brain of patients with Alzheimer's and other degenerative diseases.

It went too far beyond the court's ruling on DNA, critics claimed, by suggesting that other naturally derived products — including chemical compounds, vaccines, seeds, and antibodies — must be «significantly different» from anything found in nature or else be immediately tossed out as patent ineligible.

The team is now going to search for novel antibiotic compounds from other microorganisms by applying similar methods.

Other varieties of JIC tomatoes high in a variety of compounds such as those found in red wine are being used by Essex company Biodeb to develop a range of skincare products.

On the other hand, the optimisation of growth conditions, such as light and temperature, can also affect the compounds produced by the cells — just like in nature.

To address the urgent need for therapies, researchers supported by the National Institutes of Health screened a set of 290 compounds already approved by the U.S. Food and Drug Administration or far advanced in clinical development for other indications to determine if any might also show potential for working against MERS - CoV.

The general reaction that links the two pieces together into one big molecule has been used before by other chemists working to synthesize bryostatin 1 and related compounds.

Melittin subversively makes TRPV1 channels open by activating other enzymes that act just like those inflammatory compounds.

Experiments in 2014 on sagebrush showed some plants spoke a language dominated by camphor compounds, while others emitted more thujone, coincidentally the same chemical suspected to be responsible for the hallucinogenic effects of absinthe.