One focus in this area involves a hormone released
by our fat cells called adiponectin.
Not exact matches
The popular brew is filled with compounds
called catechins that blast belly flab
by triggering the release of
fat from
fat cells, then speeding the liver's capacity for turning that
fat into energy.
«Our stem
cell - based studies indicate that low - calorie sweeteners promote additional
fat accumulation within
cells compared with
cells not exposed to these substances, in a dose - dependent fashion — meaning that as the dose of sucralose is increased more
cells showed increased
fat droplet accumulation,» said Sabyasachi Sen, M.D., Associate Professor of Medicine at George Washington University in Washington, D.C. «This most likely occurs
by increasing glucose entry into
cells through increased activity of genes
called glucose transporters.»
The orbital remodeling in TED is likely induced
by infiltrating T lymphocytes and mast
cells, which activate orbital fibroblast effector
cells to either proliferate and form scar - producing
cells called myofibroblasts or turn into pro-inflammatory
fat cells.
The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown
fat in mice: a new small - molecule CK2 - blocker
called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2
by blocking the RNA instructions
cells use to produce it.
THE METHODS In 2000, Gerard Karsenty, a molecular geneticist at Columbia University in New York City, discovered that leptin, a hormone made
by fat cells, helps mold and repair the skeleton
by acting upon bone - building
cells called osteoblasts.
The upshot of the study, another indictment of the so -
called Western diet (high in saturated
fats, sugar and red meat), reveals how the metabolites produced
by the bacteria in the stomach chemically communicate with
cells, including
cells far beyond the colon, to dictate gene expression and health in its host.
In research published in December 2013, the investigators found that high levels of IKK - ε and TBK1 meant that certain receptors in the
fat cells of obese mice were unable to respond to neurotransmitters
called catecholamines, which are generated
by the sympathetic nervous system and promote «
fat - burning.»
The current study revealed that amlexanox exerts its effects through a specialized type of
fat cell by increasing the level of a second messenger molecule
called cAMP.
The high -
fat diet without the flavanones increased the levels of
cell - damage markers
called thiobarbituric acid reactive substances (TBARS)
by 80 percent in the blood and 57 percent in the liver compared to mice on a standard diet.
Originally, however, they were not examining brown
fat thermogenesis, but instead were looking for clues to the function of ERRβ, a protein about which little was known at the time, except that it was closely related to ERRα, appeared in brown
fat cells, and also worked as a so -
called nuclear receptor — a molecular switch for gene activation that can be turned on
by small lipophilic molecules or a signaling protein partner.
The researchers showed for the first time that brown
fat cells deliver these microRNAs into the blood
by packaging into so -
called exosomes, which «can be seen as little packages that are delivered
by the brown
fat cells through the circulation.»
Cells from many organisms recycle their parts
by breaking down sugars,
fats, and proteins in a process
called autophagy («self eating»).
In a paper published Feb. 19 in Nature
Cell Biology, the scientists show that a cutting - edge technique
called asymmetric flow field - flow fractionation (AF4) can efficiently sort nano - sized particles,
called exosomes, that are secreted
by cancer
cells and contain DNA, RNA,
fats and proteins.
In their recent study, the UCSF team reports the discovery that a class of commonly prescribed Type - 2 diabetes drugs,
called TZDs (thiazolidinediones, such as Actos and Avandia), promoted the conversion of white
fat cells into brown (in mice and culture dishes)
by stabilizing the PRDM16 protein.
In 80 percent of women,
by the time ovarian cancer is diagnosed, it has spread to the pad of
fat cells,
called the omentum.
The fatty acids are then absorbed
by cells lining the intestinal villi and converted into so
called «chylomicron» particles that enter the lymphatic system and eventually are stored as «
fat» in convenient places like hips and thighs.
is not as simple as saying that over-eating post-exercise is caused
by a greedy stomach or our body's so -
called «
fat cells» being resistant to slimming down.
That's what your
fat cells do when they expand: they send signals to your brain
by way of a hormone
called leptin to tell the brain how much
fat is in your body.
In 1994, it was discovered that a protein hormone
called leptin, which is released from
fat cells and monitored
by the brain, was deficient in a certain strain of genetically mutated obese mice.
The body does this
by first converting
fat into what are
called ketones that the
cells can then burn as fuel.
So the liver starts trying to offload the
fat by dumping it back into the bloodstream in the form of something
called VLDL, and that starts building up in the
cells of the pancreas that produce the insulin in the first place.
Insulin also interacts with a hormone
called leptin, which is created
by fat cells in response to calorie intake.
He said persistent organic pollutants,
called «POPs» for short, are most worrisome because, once consumed, they tend to adhere to organisms»
fat cells where they are metabolized
by the body and cause health problems.