Sentences with phrase «by oxidative stress in»

One of the many benefits that the beta carotene nutrient in pumpkin provides for our bodies is reducing organ damage brought on by oxidative stress in the body.

Not exact matches

Results of the study showed that the total antioxidant capacity in the bloodstream of the participants increased, and that their level of oxidative stress (as measured by the amount of carboxymethyllysine in their blood serum) decreased.

Purple sweet potato color attenuates oxidative stress and inflammatory response induced by d - galactose in mouse liver.

The researchers added: «Other bioactive compounds present in nuts, including micronutrients, fibre, and phytochemicals, may also contribute to their cardio - protective effect by reducing inflammation, improving vascular reactivity as well as fasting glucose and insulin sensitivity, and by lowering oxidative stress status.

Because the toxicity is associated with oxidative stress and inflammation, the study explored antioxidant and anti-inflammatory effect of virgin coconut oil (VCO) supplementation in nephrotoxicity induced by MTX in rats.

The researchers experimented with inducing oxidative stress in a human cell line culture with and without VCOP (virgin coconut oil polyphenols) to observe how VCOP positively promoted catalase, a very important enzyme in protecting the cell from oxidative damage, and glutathione (GSH), a self - recycling antioxidant produced by the liver.

The in - vivo (animal) study «Enhanced memory in Wistar rats by virgin coconut oil is associated with increased antioxidative, cholinergic activities and reduced oxidative stress» was published in January of 2017.

The rats fed VCO had significantly less oxidative stress markers in their kidneys than the 5HPO fed rats, leading the researchers to conclude ``... virgin coconut oil has a potential to reduce the development of hypertension and renal injury induced by dietary heated oil, possibly via its antioxidant protective effects on the kidneys.»

By controlling inflammation and upregulating antioxidant systems in the body, we can help keep our mitochondria healthy by protecting their DNA from oxidative stress (6By controlling inflammation and upregulating antioxidant systems in the body, we can help keep our mitochondria healthy by protecting their DNA from oxidative stress (6by protecting their DNA from oxidative stress (6).

The UMD and UMB team, led by research associate Eunkyoung Kim, used a discovery - driven approach based on the assumptions that chemical biomarkers relating to oxidative stress could be found in blood, and that they could be measured by common electrochemical instruments.

While pursuing her project on how environmental contaminants and oxidative stress cause lung cancer, Gelhaus complemented her postdoctoral training by spending some time with other PIs at Penn. «She has worked hard to develop skills that are independent of those available in my own laboratory while working on a project that is central to my research program,» Blair writes in an e-mail to Science Careers.

«The chemicals produced by cooking meats at high temperatures induce oxidative stress, inflammation and insulin resistance in animal studies, and these pathways may also lead to an elevated risk of developing high blood pressure,» said Gang Liu, Ph.D., lead author of the study and a postdoctoral research fellow in the department of nutrition at the Harvard T.H. Chan School of Public Health in Boston.

In several studies, vitamin C administration attenuated the increases in oxidative stress markers caused by exercisIn several studies, vitamin C administration attenuated the increases in oxidative stress markers caused by exercisin oxidative stress markers caused by exercise.

In a series of cell - based studies, they showed that it both blocked a family of iron - containing, oxygen - sensing enzymes called hypoxia - inducible factor prolyl - hydroxylases (HIF - PHD) and, critically, protected neurons by activating genes that protect them from oxidative stress.

They can provide a range of beneficial effects, such as lowering inflammatory cytokines (chemicals released by the immune system that can cause problems in rheumatoid arthritis patients), reducing joint stiffness and pain, as well as lowering oxidative stress — the ability of the body to counteract or detoxify harmful chemicals.

«Oxidative stress caused by exposure to air pollutants may therefore play a role in the development of insulin resistance.

While nicotine decreases appetite by affecting the brain and some hormone levels, it results also in increased oxidative stress.

The increase in MMP - 13 activity could be triggered by oxidative stress, which is also a hallmark of diabetic peripheral neuropathy.

Therefore, the primary novelty of the discoveries reported here is that programming by prenatal chronic hypoxia of cardiac and vascular dysfunction in adulthood follows the induction of oxidative stress in the fetal heart and vasculature, and that cardiac and endothelial dysfunction in adulthood can both be prevented by maternal treatment with antioxidants during pregnancy.

Effects of oxidative stress induced by high dosage of dietary iron ingested on intestinal damage and caecal microbiota in Chinese Yellow broilers — Z. Y. Gou — Journal of Animal Physiology and Animal Nutrition

Impaired transcriptional activity of Nrf2 in age - related myocardial oxidative stress is reversible by moderate exercise training.

Mitochondrial calcium and its regulation in neurodegeneration induced by oxidative stress.

Transcriptional repressor Rex is involved in regulation of oxidative stress response and biofilm formation by Streptococcus mutans.

In Ames dwarrf, Snell Dwarf mice, Klotho mice, GHKO mice who have little IGF and GH; and live longer than wild - type; we see that indeed insulin and glucose / nutrient / energy pathways (which create oxidative stress through excessive nutrient via elevated glycation blood glucose creating high glycated albumin and hemoglobin), that aging is acted on by IGF through hormones, GFs, GHs, acting on insulin signals, which act on survival genes (DAF / SIRT / FOXO).

Significantly, cellular pathologies including impaired cellular trafficking and an increase in oxidative stress, were reduced by treatment with the identified compound.

«Mitochondrial dysfunction, oxidative stress and apoptosis revealed by proteomic and transcriptomic analyses of the striata in two mouse models of Parkinson's disease.

Oxidative stress in fibroblasts induces the autophagic destruction of mitochondria, by mitophagy.

Oxidative stress is generated by reactive oxygen species (ROS) produced in response to metabolic activity and environmental factors.

In the absence of cellular oxidative stress, Nrf2 levels in the cytoplasm are maintained at low basal levels by binding to Keap1 and Cullin 3, which leads to the degradation of Nrf2 by ubiquitination [2], [5]--[9In the absence of cellular oxidative stress, Nrf2 levels in the cytoplasm are maintained at low basal levels by binding to Keap1 and Cullin 3, which leads to the degradation of Nrf2 by ubiquitination [2], [5]--[9in the cytoplasm are maintained at low basal levels by binding to Keap1 and Cullin 3, which leads to the degradation of Nrf2 by ubiquitination [2], [5]--[9].

Carla J. Siegfried, MD Washington University School of Medicine, St. Louis, MO Funded by The Alcon Foundation Project: Pathological Alterations in the Trabecular Meshwork Following Vitrectomy and Lens Extraction: A Model of Oxidative Stress

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

Insulin benefits of exercise «One previous small study found that trained and untrained people who dose up on antioxidant supplements impair important exercise training adaptations such as improved insulin sensitivity and production of special proteins that actually help defend the body against oxidative stress caused by exercise,» says Tim Crowe, Associate Professor in the School of Exercise and Nutrition Sciences at Deakin University and founder of Thinking Nutrition.

Oxidative stress during and after a workout «Now researchers have extended this study by looking at the effect of antioxidants in trained female runners,» says Crowe.

When you breathe deeply (deep diaphragmatic breathing) you lower the levels of oxidative stress in your body, which is caused by working out.

It's rich in antioxidants, potent phytonutrient glucosinolates and contains compounds known as bioflavonoids such as kaempferol which combat inflammation by cooling the body and inhibiting the effects of oxidative stress and weight gain.

Oxidative stress in cells is apparently caused by defective nucleoli.

Also, the antioxidants in this revitalizing health drink fight oxidative stress caused by too much alcohol.

A 2011 study in the Pakistan Journal of Biological Sciences by Mazloom et alfound that vitamin c supplementation «can decrease fasting and postprandial oxidative stress and may prevent diabetes complication» (13).

Nuts are high in phytate, which is a powerful antioxidant that promotes the growth of beneficial bacteria by protecting them from reactive oxygen species (oxidative stress).

By reducing blood sugar, ketosis significantly reduces the oxidative stress in the body.

The researchers adopted a multi-step approach to understanding asthma development, by investigating the non-enzymatic and the enzymatic ways that oxidative stress in asthma development is managed by the body.

Moreover, LA prevented the prostatic hyperplasia induced by testosterone in rats, triggered apoptosis in colon cancer cells through oxidative stress and improved the sensitization of the EGFR inhibitor cetuximab in KRAS / BRAF mutated colorectal cancer cells.

Researchers have investigated the effects of refined sugars on cognitive function, and conclude that «Special care in food selection at meals should be exercised by those with type 2 diabetes since ingestion of rapidly absorbed, high — glycemic index carbohydrate foods further impairs medial temporal lobe function, with food - induced increases in oxidative stress and cytokine release likely explaining the association between food ingestion and reduction in cognitive function in those with type 2 diabetes (1).»

Stress resistance has not been assessed however and so the biological relevance of this finding is currently unknown.32 Several IER trials (75 - 85 % ER on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research DireStress resistance has not been assessed however and so the biological relevance of this finding is currently unknown.32 Several IER trials (75 - 85 % ER on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directioin overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directioin various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Direstress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directioin one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directioin the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research DirectioIn a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directioin reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directioin the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directioin the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directioin the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directioin which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directioin AOPP in both groups after three months.48 Summary and Future Research Directioin both groups after three months.48 Summary and Future Research Directions

So we have this oxidative stress panel, and by the way also at bengreenfieldfitness.com/cortisol2, cortisol, the number two, I'll link to this if you wan na pull it up and see what an oxidative stress profile looks like, if you're listening in,»cause this one's pretty fascinating.

Also noted by IER studies are an increase in the expression levels of silent mating type information regulation 2 homolog 1 (SIRT1), an NAD + - dependent deacetylase.20 The expression of SIRT1, also increased by prolonged ER in rodents, is linked to the up - regulation of cellular stress resistance and improved outcomes in animal models of metabolic, neurodegenerative and inflammatory diseases.106, 107These findings have been suggestively accompanied by improvements in resilience to disease progression in rodent models of Type 1 diabetic nephropathy 20, survival following induced ischaemic injury 21 and a reduction in oxidative stress.105

Several trials have demonstrated that the cardiomyocytes of rodents maintained on IER become more resilient to ischaemic injury induced by occlusion of the left coronary artery 18, 21, 29, which translated into improved long - term survival following such injury in one study.21 In addition, within these studies, associations have been found between the cardiovascular improvements and markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular healtin one study.21 In addition, within these studies, associations have been found between the cardiovascular improvements and markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular healtIn addition, within these studies, associations have been found between the cardiovascular improvements and markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular healtin circulating levels of adiponectin.29 Collectively, these reported changes in biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular healtin biochemical and physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular health.

This effect is achieved by the lowering of blood pressure in cases of diabetic patients, decreasing oxidative stress on the sensitive sperm cells and therefore minimising damage to their DNA cargo4.

Such damage can be caused by an autoimmune attack on the gland, oxidative stress, surgical removal of the thyroid and the use of radioactive iodine in the treatment of hyperthyroidism.