Sentences with phrase «by palbociclib»
The researchers used a novel method called thermal proteome profiling to detect cellular changes induced by palbociclib.
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«While it was known that palbociclib stalls proliferation by inhibiting CDK4 / 6, inducing proteasomal activity may be an additional mechanism that ensures the completeness of the cell cycle arrest,» says Dr. Mikael Björklund, one of the lead authors of the study.
The breast cancer drug palbociclib arrests cells in G1 phase by CDK4 / 6 inhibition, but also causes cellular senescence.
The proteasome is a novel downstream target for the anti ‐ cancer drug palbociclib inhibiting proliferation by reduced proteasomal association with its inhibitor EMC29.
Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4 / 6 inhibitor palbociclib, The EMBO Journal (2018).
However, recent observations indicate that palbociclib induces a more complete arrest than what can be achieved by blocking CDK4 / 6.