The study,
funded by the Pancreatic Cancer Research Fund, examined the role of Hedgehog, whose usual job is to send signals to cells in embryos to divide and grow into the correct body parts.
«One promising strategy to reduce the number of people
affected by pancreatic cancer is to identify and treat premalignant pancreatic lesions,» said first author Jennifer Permuth - Wey, Ph.D., M.S., assistant member in the Departments of Cancer Epidemiology and Gastrointestinal Oncology at Moffitt.
The study, funded in part
by the Pancreatic Cancer Action Network and The National Pancreas Foundation, also was the first to evaluate a test that employed a more sensitive genetic sequencing method called next - generation sequencing and the first to be performed in a certified and accredited clinical laboratory as opposed to a research setting.
But their overriding interest in BPTES, says Slusher, was in how it works: by blocking the production of glutamine, an amino acid that acts as a building block of cells and is used
frequently by pancreatic cancers to create more cancer cells.
Our understanding of the basis of immune suppression is evolving, but we know that it involves the production of the chemokine, CXCL12, by the fibroblastic stromal cells, binding of this
CXCL12 by pancreatic cancer cells, and exclusion of T cells from the vicinity of the cancer cells.
The life of the NASA astronaut and science campaigner Sally Ride was cut
short by pancreatic cancer on Monday, but her influence will long endure.
Any not - for - profit patient advocacy organization that provides services or disseminates information to those
affected by pancreatic cancer can become a member of the World Pancreatic Cancer Coalition.
A clinical trial, funded
by the Pancreatic Cancer Action Network, has been started to see if these analyses can predict which patients at risk for pancreatic cancer will develop tumors.
The Pancreatic Cancer Action Network is a nationwide network of people dedicated to working together to advance research, support patients and create hope for those affected
by pancreatic cancer.