Sentences with phrase «by phosphorylation»

We also CREB proteins are activated by phosphorylation from various kinases, including PKA, and Ca 2 + / calmodulin - dependent protein kinases on the Serine 133

Activation of the insulin receptor involves its autophosphorylation, which is followed by phosphorylation of several target proteins in the signaling cascade.

We also found high levels of strA and strB, two resistance genes encoding for the aminoglycoside phosphotransferases APH (3 ″)- Ib and APH (6)- Id which inactivates streptomycin by phosphorylation [26].

AS160 is actually a Rab GAP, and GTP is activating protein, and by phosphorylation it prevents its action.

The translation initiation factor, eIF4E, is an indirect target of mTOR because it is released by phosphorylation of its repressor 4E - BP1 by mTOR - raptor complex, thereby stimulating cap - dependent translation (7, 11, 12).

PhoB has a well characterized DNA binding domain whose affinity for DNA is strongly enhanced by phosphorylation [17], [18], [19].

GS is covalently modified by phosphorylation at nine serine residues by several protein kinases.

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

mTOR - raptor complex is sensitive to rapamycin and regulates cell growth, in part, by phosphorylation of p70S6K and subsequently rpS6 and 4E - BP1, thus promoting protein translation.

We also show that a general repression of translation, mediated by the phosphorylation of translation initiation factor eIF2 at serine 51 (P - eIF2α), is required to maintain the quiescent state.

Regulation of TDP - 43 aggregation by phosphorylation andp62 / SQSTM1.

Not exact matches

«Structural analysis of phosducin and its phosphorylation - regulated interaction with transducin beta - gamma» by Rachelle Gaudet Pros: A great dance that is incredibly fun to watch.

A Smo agonist stimulated and a Smo antagonist (cyclopamine) inhibited both phosphorylation of Smo by GRK2 and interaction of β - arrestin 2 with Smo.

Adenosine 3», 5» - monophosphate at a concentration of 5 x 10 - 7 mole per liter causes a 400 percent increase in the rate of phosphorylation of histone catalyzed by a partially purified enzyme preparation from rabbit brain.

In 1996, Peter Klein of the University of Pennsylvania discovered that one of lithium's biological activities was inhibiting GSK - 3, an enzyme that modifies other proteins by attaching phosphate molecules, a process called phosphorylation.

Cellular transfection of β - arrestin 2 caused cytosolic retention of JNK3 and enhanced JNK3 phosphorylation stimulated by ASK1.

These and other observations suggest that many different classes of regulatory substances achieve certain of their biological effects by altering the phosphorylation of specific proteins.

The research team, led by Professor Yoshiaki Ito, Senior Principal Investigator at CSI Singapore, found that a modification called phosphorylation made to RUNX3 promotes cancer progression by allowing cell division.

Tim Clausen's group at the Research Institute of Molecular Pathology (IMP) in Vienna identified an analogous system in gram - positive bacteria, where the role of a degradation tag is fulfilled by a little known post-translational modification: arginine phosphorylation.

Ueda's group performed experiments to show that phosphorylation activates WRKY2 by using mutants absent of SSP and replaced serine residues in WRKY2 with asparagine by base exchange, which mimics serine phosphorylation.

In this study, by using a systemic mtEF4 gene knockout mouse model, researchers found that mtEF4 knockout damages the oxidative phosphorylation function in germ cells of male mice, thus causing male sterility.

During the development of blood cells it is activated by tyrosine phosphorylation and can switch certain genes on or off.

Hund's team identified a phosphorylation site (Serine 571) on the voltage-gated sodium channel targeted by CaM kinase II that serves as a switch for inappropriate «late» sodium influx.

«We realized that studying the lithium response could be used as a «molecular can - opener» to unravel the molecular pathway of this complex disorder, that turns out not to be caused by a defect in a gene, but rather by the posttranslational regulation (phosphorylation) of the product of a gene — in this case, CRMP2, an intracellular protein that regulates neural networks,» added Snyder.

A key step in many signaling pathways is «phosphorylation,» the activation or deactivation of a protein by adding a phosphate group at certain sites on the protein.

In regions infected by H5N1 virus, we observe activation of microglia and alpha - synuclein phosphorylation and aggregation that persists long after resolution of the infection.

In naïve cells, receptor dimerization is effectively induced by all IFNs, leading to phosphorylation of pre-associated STAT1 / STAT2 / IRF9 complexes, which subsequently form the transcription factor ISGF3.

They discovered that stress - activated phosphorylation of ADAR1p110 by MKK6 - p38 - MSK MAP kinases promotes its binding to Exportin - 5 and export from the nucleus.

Interestingly, this anti-apoptotic function of ADAR1 is regulated through its phosphorylation by MAP kinases.

Regulation of sororin by Cdk1 - mediated phosphorylation.

Phosphorylation of the nuclear form of varicella - zoster virus immediate - early protein 63 by casein kinase II at serine 186.

Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin - dependent kinases in Saccharomyces cerevisiae.

Specifically, they are interested in those genes that are involved in tyrosine phosphorylation — the attachment of a phosphate group (a phosphorous surrounded by oxygen atoms) to distinct sites in protein chains where there is a tyrosine residue.

The SDF - 1 / CXCR4 interaction stimulates tyrosine phosphorylation of CXCR4, followed by the activation of multiple G protein - dependent signaling pathways, which may be different among cell types.

An InCytes from MBC Selection: Regulation of Cell Polarity through Phosphorylation of Bni4 by Pho85 G1 Cyclin - dependent Kinases in Saccharomyces cerevisiae.

x Phosphorylation of Bax Ser184 by Akt Regulates Its Activity and Apoptosis in Neutrophils.

The function and dynamics of the apical scaffolding protein E3KARP are regulated by cell - cycle phosphorylation.

Phosphorylation of tumor necrosis factor receptor CD120a (p55) by p42 mapk / erk2 induces changes in its subcellular localization.

AKT phosphorylation was Tie2 - dependent as evidenced by shRNA - mediated Tie2 silencing experiments (Fig. 1i — l, Supplementary Fig. 2a, b).

Mitotic - dependent phosphorylation of leukemia - associated RhoGEF (LARG) by Cdk1.

Phosphorylation of Src by phosphoinositide 3 - kinase regulates beta - adrenergic receptor - mediated EGFR transactivation.

Phosphorylation of Merkel cell polyomavirus large tumor antigen at serine 816 by ATM kinase induces apoptosis in host cells.

Secretagogue - dependent phosphorylation of the insulin granule membrane protein phogrin is mediated by cAMP - dependent protein kinase.

Acute Ethanol Increases IGF - I - Induced Phosphorylation of ERKs by Enhancing Recruitment of p52 - Shc to the Grb2 / Shc Complex.

The effect of insulin on phosphorylation of Akt protein was measured by Western blot in enhanced hiPS - HEP cells from C18 on Day 12 post-thawing (n = 3 for the [+] condition; n = 1 for the -LSB----RSB- control).

Akt phosphorylation at pS473 was also measured by ELISA (Thermo Fisher Scientific).

Theret et al. identify LDH as a new functional target of AMPKα1 in MuSCs, where it is a direct regulator by which the oxidative phosphorylation / aerobic glycolysis balance can be shifted to control differentiation / self - renewal.

Thus the phosphorylation of CREB by J147 could increase the levels of BDNF, which consequently may increase BDNF responsive proteins.

mTOR - rictor complex (composed of mTOR, rictor, and GβL) is not rapamycin sensitive and modulates cell survival and proliferation by direct phosphorylation of AKT on Ser473 and by facilitating AKT phosphorylation on Thr308 by PDK1 in vitro (13).

The routes of these multisite phosphorylation cascades are determined by precisely oriented docking interactions mediated by cyclin - specific docking motifs and by Cks1, the phospho - adaptor subunit of Cdk1.