Sentences with phrase «by resistance to therapy»

This high mortality is primarily caused by resistance to therapy and the diagnosis of ovarian cancer after it has already metastasized, which occurs in approximately 80 percent of patients.

Not exact matches

«Antibiotic resistance is not likely to occur because the bacteria therapy is attacking pathogens by multiple different ways at once.»

They have also discovered that a protein named Wnt5A promotes metastatic progression, resistance to therapy and poorer prognosis, and one of the ways in which it is regulated is by the anti-aging protein Klotho.

My cancer systems biology team at the University of California, Merced, is tackling diagnosis and treatment of therapy - resistant cancers by elucidating the network of changes within cells as a way to identify new drug targets and circumvent cancer resistance.

«By helping us understand that lower levels of RNF125 confer resistance to BRAF inhibitors, we have a new strategy to stratify patients for currently approved therapy versus participation for human clinical trials to investigate whether targeting JAK1 will be more effective in patients whose tumors exhibit reduced RNF125,» said Keith T. Flaherty, M.D., associate professor, Harvard Medical School, and director of Developmental Therapeutics, Cancer Center, Massachusetts General Hospital, and co-author of the study.

Field reports suggest that not all K13 mutations are capable of causing resistance, and the genetic system developed by Dr. Fidock to study K13, based on DNA repair approaches that are being used in human gene therapy studies, will be critical in identifying real hot spots of resistance.

Though malaria deaths have dropped by 30 percent worldwide since the introduction of artemisinin - based combination therapies (ACTs) in the late 1990s, these gains are now threatened by the emergence of resistance to the core artemisinin component of ACTs in Southeast Asia.

«Current therapies take advantage of this by using targeted drugs such as Trastuzumab or Lapatinib to specifically inhibit ERBB2, but eventually they become ineffective as the cancer develops resistance to those drugs.»

«Understanding how the drugs work gives us the opportunity to investigate new treatments, for example by using combination therapies, or altering the dosage and timing of treatment to prevent drug resistance from emerging,» Dr Glaser said.

In the present study, the scientists demonstrated that the drug BI-97D6 increased cancer cell death caused by mda - 7 / IL - 24, and it also helped defend against resistance to the viral gene therapy.

Wu added that in this respect, the response generated by a neoantigen vaccine is similar to the new wave of combination therapies, which are showing more promise in treating cancers that typically develop resistance to single drugs.

However, unfortunately, the vast majority of patients do not respond to checkpoint inhibition therapy and a minority of patients, who do respond to treatment, develop secondary resistance and experience relapse by mechanisms still inadequately understood.

A Ludwig Cancer Research study has uncovered a key mechanism by which tumors develop resistance to radiation therapy and shown how such resistance might be overcome with drugs that are currently under development.

We seek to «Track and Treat» the cancer cells present in patients» tissues by using lineage tracing, as well as sequencing technologies, to determine the molecular mechanisms responsible for the dissemination of cancer cells to various organs, and resistance to current therapies.

We hope CBS - based combination therapy will open up a new horizon for the treatment of infection caused by superbugs, serving as a new and more economical therapy to solve the problem of antimicrobial resistance (AMR).»

More importantly, the brand - new therapy allows the dose of antibiotics to be reduced by 90 percent to attain the same level of effectiveness, and the development of NDM - 1 resistance to be significantly slowed down, which will largely extend the life cycle of currently used antibiotics.

Areas covered by Cancer Cell include, but are not limited to, molecular and cellular mechanisms of cancer, mechanisms for the sensitivity and the resistance to cancer therapies, and development of better cancer therapies.

These research studies improve our understanding of the disease by uncovering the mechanisms of response and resistance, potentially gaining insight that would allow us to predict the future patients who will benefit from each of these treatments and to develop new therapies that are even more effective.

Led by Christiana Davis, MD, (in collaboration with Dr. Peter Gabriel, Chief Oncology Informatics Officer and Abigail Doucette, MPH, Research Registry Program Manager), the Thoracic TCE has established project - based databases to track the demographics and response status of patients to immune - oncology treatments, as well as acquired resistance to standard therapies and novel targeted immunotherapies.

This work, and that of colleagues Brian Druker and Novartis, led to the development of the kinase inhibitor imatinib (Gleevec) as primary therapy for chronic myelogenous leukemia (CML), and the discovery that imatinib resistance is caused by BCR - ABL kinase domain mutations.

Several studies reviewed indicated that using yoga as therapy combated insulin resistance by improving fasting glucose (with improvements ranging from a 5.4 % to a 33.4 % decrease in fasting glucose levels), postprandial glucose levels (blood sugar levels after meals), and glycohemoglobin levels (a measure of the long - term control of diabetes mellitus).

Some practitioners, however, also use it as part of their therapy and is an example of biofeedback, defined here as a method of improving muscle function and correcting imbalance by consciously responding to the stimulation of pressure resistance by another person (such as a therapist) against a muscle.

Low - dose supplemental testosterone treatment in men with chronic stable angina increased exercise time preceding induced myocardial ischemia as defined by ST depression on EKG.80 Testosterone replacement therapy has also been proven to reduce insulin resistance, visceral adiposity, and cardiovascular risk.

As an arts therapist, my choice to pursue another qualification, was informed by the fact that I often witnessed people's resistance when considering the possibility of asking for help and starting therapy.

The need for a protective separation of the child is made necessary on two grounds, 1) to protect the child from continued exposure to the psychological child abuse associated with the pathogenic parenting of the narcissistic / (borderline) parent, and 2) to prevent psychological harm to the child during the active phase of treatment as a result of being turned into a «psychological battleground» by the continued active resistance of the narcissistic / (borderline) parent to the goals of therapy, and from the continued motivated efforts of the narcissistic / (borderline) parent to maintain the child's symptomatic state even as therapy seeks to resolve the child's symptoms.

We want to address that whether it's by therapy or some kind of other intervention process to get the underlying cause of the child's resistance.