In the current study, the team found that these longer bacteria were least affected
by rifampicin.
Not exact matches
Vitamin C had no activity
by itself, but in two independent experiments, the combination of vitamin C with the first - line TB drugs, isoniazid and
rifampicin, reduced the organ burdens faster than the two drugs without vitamin C, said first author Catherine J. Vilcheze, Ph.D..
The study followed 1,055 household contacts of 213 individuals with MDRTB infection (defined
by resistance to the drugs
rifampicin and isoniazid), and 2,362 household contacts of 487 individuals with drug - susceptible tuberculosis for up to three years.
Drug resistance in
rifampicin and related antibiotics has occurred when their bacterial RNA polymerase enzymes mutate, Mahmud said, leaving them largely unaffected
by antibiotics that work
by inhibiting RNA synthesis.
The intensive treatment for pulmonary TB is a six - month regime that consists of two months of isoniazid,
rifampicin, pyrazinamide, and ethambutol, followed
by four months of isoniazid and
rifampicin in FDCs that are combined in one tablet, or separately as single - drug formulations.