Sentences with phrase «by single genes»

Because disease organisms mutate quickly to overcome crop resistance controlled by single genes, researchers are rushing to identify new resistance genes and to incorporate multiple genes into high - yielding varieties, according to Ravi Singh, CIMMYT wheat scientist who participated in the reported study.

«Most PRAs, including the one in Phalenes and Papillons, are recessive and caused by single gene defects and small sample numbers can lead to breakthroughs.

It is caused by a single gene abnormality which leads to the production of a mutant form of a protein called huntingtin (mHtt).

In the intervening years, we have come to realize that many of the most interesting and important phenomena in human biology are not caused by any single gene.

Rare, deadly, and caused by a single gene mutation, it was a perfect proof - of - principle condition for anyone seeking to replace damaged DNA with genes that did the job.

Because Huntington's is determined by a single gene, Liu was able to easily isolate its effects on the birds.

Previous research has shown that a protein produced by a single gene can potentially have different functions in a cell depending on the proteins with which it interacts.

After the gene was duplicated — now I just mention [ed] that duplication takes place all of the time, they are common sort of genetic accidents — but after the genes were duplicated, now there was the opportunity to divide the labor that was once stored by a single gene; now divide that labor into two genes, and what happened is, a series a mutations have taken place that has optimized each role — that the regulatory sensor role of GAL3 and the enzymatic - converting role of GAL1.

In a sign of the method's power, Pritchard's team also detected selection in traits controlled not by a single gene, but by tiny changes in hundreds of genes.

While the disease is caused by a single gene mutation, the manifestation of the disease at a molecular level is nevertheless highly complex and involves multiple cellular processes.

Unlike some other common vision disorders, such as age - related macular degneration, color blindness is a heritable disorder caused by a single gene that is defective or absent.

Rather than being triggered by a single gene mutation, the tumors are caused by too many or too few copies of a gene in a person's cells.

An enzyme encoded by a single gene, for example, can regulate the synthesis of many different lipids.

Semenza's team uncovered the mitochondrial mechanism in a study of Von Hippel - Lindau (VHL) syndrome, caused by a single gene mutation and characterized by the tendency to develop tumors in many parts of the body, including the kidney, brain and adrenal glands.

But human altruism can not possibly be controlled by a single gene, and different genes that might produce altruistic behavior probably interact, making the kin selection equation quite a bit more complicated.

The team of researchers in collaboration with Patricia Okubura, a USDA - ARS research geneticist, confirmed that resistance was conferred by a single gene.

This means the disease was determined by a single gene.

This means that it is not associated with the sex chromosomes, but simply determined by a single gene that one parent can pass to an offspring, the result having varying degrees of severity.

These traits are controlled by a single gene that is ultimately located on a single chromosome pair.

Conditions that are controlled by a single gene fall into one of four inheritance patterns.

Not exact matches

Each inherited trait is determined by one or more genes and is not a feature of a single type - pattern as required by the blood theory.

But, as journalist Steve Connor reports, the reference to editing was intentional: «Scientists have used the genome - editing technology to cure adult laboratory mice of an inherited liver disease by correcting a single «letter» of the genetic alphabet which had been mutated in a vital gene involved in liver metabolism.»

Lacking money to outfit the new lab, Wang and Xin bought used equipment: a single channel DNA sequencer (bought and barely touched by a Harvard Medical School researcher); second - hand centrifuges and pipettes; a reconditioned CytoScan HD system that detects variations in the number of copies of a gene.

«This Y is encoded by one single gene sequence.

New research at the University at Buffalo reveals the first evidence that it may be possible to use a single compound to alleviate the behavioral symptoms by targeting sets of genes involved in the disease.

In 1986 my research group at the Rockefeller University and another led by Jeffrey Hall of Brandeis University and Michael Rosbash of the Howard Hughes Medical Institute at Brandeis found that the three mutant flies had three different alterations in a single gene named period, or per, which each of our teams had independently isolated two years earlier.

A rare condition that causes a person be born without fingerprints can now be explained by a mutation in a single gene, a new analysis suggests

Many are known to be caused by mutations in single genes, yet for the vast majority no treatments are available.

By taking blood immediately after before and after performing the technique on a single day, researchers also showed that the gene changes happened within minutes.

Alpha -1-antitrypsin deficiency (A1ATD) is the most common genetic disease of the liver, and is caused by a single nucleotide change in the gene that codes for alpha -1-antitrypsin (A1AT), an enzyme inhibitor that normally protects bodily tissues.

A single miRNA can ramp down expression of multiple genes — but the number of genes affected by known miRNAs hasn't been determined.

By using engineered zinc - finger nucleases (ZFNs) designed to target an integrated reporter and two endogenous rat genes, Immunoglobulin M (IgM) and Rab38, we demonstrate that a single injection of DNA or messenger RNA encoding ZFNs into the one - cell rat embryo leads to a high frequency of animals carrying 25 to 100 % disruption at the target locus.

To generate the models, Jackson created two mutated versions of the PrP - coding gene by changing a single codon — one of the three - nucleotide «words» in genes that code for the various amino acids in proteins.

When the researchers compared the mRNA to a library of DNA sequences taken from the dendrites of neurons by James Eberwine of the University of Pennsylvania Medical Center, they found that it came from a single gene on chromosome X — the human version of which, when mutated, leads to fragile - X syndrome.

SMA1 is a progressive, childhood, neuromuscular disease caused by a mutation in a single gene.

Almost immediately such familial genome sequencing proved its value, uncovering mutations responsible for diseases caused by defects in a single gene.

Tadashi Matsunaga at the Tokyo University of Agriculture and Technology in Japan and his colleagues singled out the genes by comparing well - known magnetic bacteria to a distantly related magnetic species.

Unlike other autoimmune disorders with associated risk factors, APECED is clearly caused by a mutation in a single gene, based on analyses of affected families.

Such plants have two mutant copies of a gene called hothead, which differ from the normal gene by a single base pair.

The samples were analyzed by liquid chromatography - mass spectrometry (LC - MS) to characterize the metabolite composition («metabolomics»), and biocrust DNA was extracted for shotgun sequencing to measure single copy gene markers for the dominant microbe species («metagenomics»).

In the U.S., this behavioral division follows a genetic one: workers bearing two copies of one form, or allele, of the Gp - 9 gene live in nests governed by a single matriarch, whereas those that have one copy or a pair of a second allele take orders from a female oligarchy.

The two studies together suggest that single copies of inactivating ANGPTL3 mutations are found in roughly one of every 250 people of European descent, whereas people with mutations in both copies of the gene — as in the family studied by Musunuru and colleagues — are much rarer.

This allows us to discern between viral strains that may even be different by just a single gene mutation.»

The results of the study were obtained by infecting laboratory - grown cells with forms of the CMV virus which differed only by the removal of a single gene.

To avoid that muddle, Steve Brown and Xue - Zhong Liu, molecular biologists at the Medical Research Council's Mouse Genome Center in Harwell, England, sought families in remote areas of the world, where the families» deafness is more likely to be caused by a single mutated gene.

Cystic fibrosis, achondroplasia, phenylketonuria and Huntington's disease are each caused by simple changes in the sequence of a single gene.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study published June 18th in the journal Cell.

«Single - nucleus RNA sequencing, droplet by droplet: DroNc - Seq, technology that merges single - nucleus RNA sequencing with microfluidics, brings new scale to gene expression studies in complex tissues.&Single - nucleus RNA sequencing, droplet by droplet: DroNc - Seq, technology that merges single - nucleus RNA sequencing with microfluidics, brings new scale to gene expression studies in complex tissues.&single - nucleus RNA sequencing with microfluidics, brings new scale to gene expression studies in complex tissues.»

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Sickle cell disease is a recessive genetic disorder caused by a single mutation in both copies of a gene coding for beta - globin, a protein that forms part of the oxygen - carrying molecule hemoglobin.