Sentences with phrase «by small molecule compounds»

In melanoma, the MAPK and PI3K pathways are primary targets for therapy, but other pathways are also explored for inhibition by small molecule compounds.

Not exact matches

To try to develop a more sensitive probe for isolating individual peptides — short strands of amino acids — from a pool of similar molecules, a team led by chemist Clark Still of Columbia University 4 years ago synthesized small organic compounds that selectively fish out peptides dissolved in chloroform.

3BP, part of a class of compounds known as small molecule drugs, was first studied as an anti-cancer agent more than a decade ago at Johns Hopkins by biochemists Young Hee Ko and Peter Pedersen, together with radiologist Jeff Geschwind.

Towards reducing the global burden of malaria and other neglected diseases, millions of compounds were screened, prioritized and assembled by the WHO - supported Medicines for Malaria Venture (MMV) as the MMV «Malaria Box» collection of 400 chemically diverse small molecules.

The scientists developed a small - molecule drug compound to prevent abnormal cellular processes caused by a mutation in the C9ORF72 gene.

The initial work identified the precursor to GS - 5734, a small - molecule antiviral agent, which led to the effort by Gilead and USAMRIID to further refine, develop and evaluate the compound.

Currently, Everon is optimizing several lead compounds: small molecules and biologics that have already demonstrated a rejuvenation effect in aging animals, as measured by a lowered mouse FI (similar FI has recently been accepted by FDA as a measure of aging in the ongoing Metformin human trial).

Shi, Y.; Desponts, C.; Do, J. T.; Hahm, H. S.; Scholer, H. R.; Ding, S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small - molecule compounds.