Sentences with phrase «by some cancer cells»

«We think some of these genes could be «hijacked» by cancer cells and may contribute to the shared invasive characteristics of the placenta and cancer,» Sutherland says.

Designing molecules that selectively target thiols produced by cancer cells that cause drug resistance is the focus of many years» work by Dimmock, Das and their collaborators.

Now, in a new study using laboratory - grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.

Targeting stromal cells as well as the cancer cells blocks multiple cell signalling pathways that are used by cancer cells to become aggressive.

One miRNA can target multiple genes, but their expression is often hijacked by cancer cells and disrupts multiple cancer - causing or tumor - suppressing pathways,» says Shuk - Mei Ho, PhD, director of the CCC and Jacob G. Schmidlapp Chair of Environmental Health and professor at the University of Cincinnati (UC) College of Medicine.

An inactive metallic nanoparticle containing iron, silver, or gold is absorbed by a cancer cell.

«Brain metastases are a secondary brain tumour, which means they are caused by cancer cells that escape from primary tumours like lung, breast or melanoma, and travel to the brain,» said Mohini Singh, the study's primary author and a PhD candidate in biochemistry at the Michael G. DeGroote School of Medicine at McMaster.

Knowing more about the activation process has led researchers to be able to induce greater vulnerability by cancer cells to an existing first - line treatment for cancers (mainly lung) driven by a receptor called EGFR.

The PKCƐ signal pathway, which is used by cancer cells but rarely by normal cells, could be important in targeting some cancer cells as they rely on this pathway to survive.

«Scientists pinpoint a new line of defense used by cancer cells.»

Cancer Research UK scientists have discovered a new line of defence used by cancer cells to evade cell death, according to research published in Nature Communications.

Just as cells of the immune system use antibodies to recognize pathogens, researchers in this study designed antibodies to recognize a protein over-expressed by these cancer cells, namely the protein mesothelin.

For example, scientists could engineer T cells, sentinels of the immune system, with genetic circuits that initiate a response to wipe out tumors when they detect the presence of two or three «biomarkers» produced by cancer cells, Lu says.

The research team suggests that this normal contact between the two cell types is exploited by cancer cells, in which contact - based, mutually reinforcing cross-talk between them turns off the immune response.

Cancer cells settle to the bottom of the well, where they selectively bind to the antibodies based on their surface markers (unlike other devices, the chip can also trap tiny structures called exosomes produced by cancers cells).

The unusual supply lines built by cancer cells may explain why some treatments fail and offer new targets for drugs.

In a paper published Feb. 19 in Nature Cell Biology, the scientists show that a cutting - edge technique called asymmetric flow field - flow fractionation (AF4) can efficiently sort nano - sized particles, called exosomes, that are secreted by cancer cells and contain DNA, RNA, fats and proteins.

«Some studies suggested that exosomes harbored the potential to regulate cancer cell metabolism, but most research had focused on the exosomes that were produced and emitted by cancer cells themselves.

«We found that exomeres are the most predominant particle secreted by cancer cells,» said senior author Dr. David Lyden, the Stavros S. Niarchos Professor in Pediatric Cardiology, and a scientist in the Sandra and Edward Meyer Cancer Center and the Gale and Ira Drukier Institute for Children's Health at Weill Cornell Medicine.

The microscope has been used to peer inside blood vessels being invaded by cancer cells and capture white blood cells while they chomp down on sugars inside a fish eyeball.

It's possible that inherited regions of CNV with strong influence on gene expression are targeted for amplification / deletion by cancer cells, which might obscure their effect in an otherwise normal cell.

Areas covered by Cancer Cell include, but are not limited to, molecular and cellular mechanisms of cancer, mechanisms for the sensitivity and the resistance to cancer therapies, and development of better cancer therapies.

Secondary rounds of tumor sequencing — possible now that the cost has fallen dramatically — could point to new mutations acquired by their cancer cells, thus suggesting further treatments.

There may also be a blood test for a substance produced by some cancer cells called carcinoembryonic antigen (CEA).

The research, published in Cell Metabolism, identified the role of a particular protein, IL - 6, released by cancer cells even before cachexia manifests.

Researchers at the Institut Curie in Paris now say that they have evidence of a coordinated attack on the basement membrane by cancer cells in situ and CAF cells in the extracellular matrix that begins long before the actual translocation of cancer cells.

Too much growth factor production by some cancer cells helps them grow quickly.

However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a selective advantage.

This process, called autophagy, is normally used by a cell to recycle damaged organelles and proteins, but is also co-opted by cancer cells to meet their increased energy and metabolic demands.

Neutrophils, the most common type of white blood cell, can be taken over by cancer cells and used as an aid in metastasis...

Through such evolutionary processes, a drug that targets telomerase could seem effective at first, only to be defeated by the cancer cell line if it can (for instance) more effectively break the drug down, or prevent the drug from entering its cells, or put out the biological equivalents of the «chaff» and flares that are used by fighter jets to ward off the targeting systems of hostile missiles.

The University of North Carolina at Chapel Hill, Washington University School of Medicine in St. Louis, and Boise State University have been named partners in one of five U.S. centers that will use genetic data to search for proteins that are abnormally made by cancer cells.

Ketones, on the other hand, can't be used by cancer cells as an energy source.

p. 187), recent research shows that celery contains high levels of the bioflavonoid apigenin which inhibits cancer growth by reducing the amount of a specific enzyme used by cancer cells.

What hasn't been understood until now is whether this excess sugar consumption by cancer cells is a symptom of cancer, or if it's a cause of cancer.

However, if the ionic colloidal silver is absorbed by a cancer cell, it may disable the pathogen inside the cell, thus allowing the cell to revert back to a normal cell.

Excess aminos — typically the end result of metabolic processes stimulated by the stress - induced release of adrenal hormones — will be available for use by cancer cells].

Dietary phytates are «quickly absorbed from the [digestive] tract and rapidly taken up» by cancer cells throughout the body, and has been shown to inhibit the growth of all tested cancerous cell lines.

But because metformin may stem cancer through several different channels — by lowering insulin, directly slowing tumor growth, or promoting suicide by cancer cells — it could potentially prove useful in many types of cancer.

In fact, while fats can be used as an energy source by normal dog cells, they can not by cancer cells.

The research team will conduct clinical trials to evaluate a novel immunotherapy treatment which combines a molecule expressed by cancer cells with a modified live form of the bacteria Listeria monocytogenes.

Nasal adenocarcinoma is a slow, progressive, local infiltration by cancer cells of tissues lining the inside of the nose.

Not exact matches

This drug has already staked its claim in the world of next - gen «checkpoint inhibitor» cancer treatments by besting rival Bristol - Myers Squibb's competing treatment Opdivo in advanced non-small cell lung cancer (NSCLC).

Immune cells modified by CRISPR - Cas9 were inserted into a lung cancer patient at the West China Hospital in Chengdu in the hopes that they'll be able to fight tumors, and 10 people total will receive injections of CRISPR re-engineered cells in order to assess the method's safety.

When placed at the site of a cancerous tumour in a rodent and «activated» by a scope with a light source, the compounds eradicated up to 100 % of cancer cells.

Chemotherapy works by killing cancer cells by targeting fast - dividing cells, and in most cases, kills off some healthy cells along the way, including nerve cells in the brain.

JCAR015 is among CAR T - cell candidates covered by Juno's 10 - year, approximately $ 1 billion global collaboration launched in 2015 to develop and commercialize cancer and autoimmune diseases immunotherapies.

Chicago, GenomeWeb — A new study by researchers from Memorial Sloan Kettering Cancer Center has demonstrated the predictive power of an AR - V7 protein expression test using Epic Sciences» non-EPCAM-based circulating tumor cell detection platform, which could help guide treatment decisions for men with metastatic castration - resistant prostate cCancer Center has demonstrated the predictive power of an AR - V7 protein expression test using Epic Sciences» non-EPCAM-based circulating tumor cell detection platform, which could help guide treatment decisions for men with metastatic castration - resistant prostate cancercancer.

Its drug Niraparib kills cancer cells by inhibiting the production of proteins called PARPs, which help repair damaged DNA strands, thereby hastening the death of some types of cancer cells.

Currently marketed for research use by Biofluidica, the test's microfluidic channels use specific cancer antibodies to detect capture circulating tumor cells.