Sentences with phrase «by subsequent developments»

Tony Crosland who set out on a mission to «destroy every fucking grammar school in England» is served particularly poorly by subsequent developments.

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Among the factors that could cause actual results to differ materially are the following: (1) worldwide economic, political, and capital markets conditions and other factors beyond the Company's control, including natural and other disasters or climate change affecting the operations of the Company or its customers and suppliers; (2) the Company's credit ratings and its cost of capital; (3) competitive conditions and customer preferences; (4) foreign currency exchange rates and fluctuations in those rates; (5) the timing and market acceptance of new product offerings; (6) the availability and cost of purchased components, compounds, raw materials and energy (including oil and natural gas and their derivatives) due to shortages, increased demand or supply interruptions (including those caused by natural and other disasters and other events); (7) the impact of acquisitions, strategic alliances, divestitures, and other unusual events resulting from portfolio management actions and other evolving business strategies, and possible organizational restructuring; (8) generating fewer productivity improvements than estimated; (9) unanticipated problems or delays with the phased implementation of a global enterprise resource planning (ERP) system, or security breaches and other disruptions to the Company's information technology infrastructure; (10) financial market risks that may affect the Company's funding obligations under defined benefit pension and postretirement plans; and (11) legal proceedings, including significant developments that could occur in the legal and regulatory proceedings described in the Company's Annual Report on Form 10 - K for the year ended Dec. 31, 2017, and any subsequent quarterly reports on Form 10 - Q (the «Reports»).

Judge Fusté's subsequent written opinion provided information that had been either knowingly or inadvertently withheld from investors by the Government Development Bank.»

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

This was followed by five subsequent phases of development in a regular pattern of succession: (1) the organization of home and foreign mission societies to channel new leadership into church planting or into the field; (2) the production and distribution of Christian literature; (3) the renewal and extension of Christian educational institutions; (4) attempts at «the reformation of manners» — i.e., the reassertion of Christian moral standards in a decadent society; and (5) the great humanitarian crusades against social evils like slavery, war and intemperance.

To suggest that we ought to return to «orthodoxy» is to suggest that we can best express our faith today by disregarding the development of human philosophy subsequent to the original, or «orthodox» expression of that faith.

(2) Subsequent developments in history have lifted this fellowship to a mountain peak where it can be seen by all of Western culture, thus revealing to us the saving power of this kind of communion.

By this we do not mean just the temporal development that historical criticism discerns in the redaction of these codes, the evolution of moral ideas that may be traced out from the first Decalogue to the Law of the Covenant, on the one hand, and from the Decalogue itself through the restatements and amplifications of the book of Deuteronomy to the new synthesis of the «Holiness Code» in the book of Leviticus and the legislation subsequent to Ezra, on the other; more important than this development of the content of the Law is the transformation in the relationship between the faithful believer and the Law.

But this is a historical question; what is important in this context is the fact that the subsequent development of Greek, medieval and modern philosophy was largely dominated by the contrast between the timeless realm of Being and the temporal realm of change; in this sense, it was a continuation of the dialogue between Parmenides and Heraclitus, with Parmenides having an upper hand.

In subsequent passage, however, he adds that it is possible to conceive «an infinite number of degrees» between matter and fully developed spirit: «Each of these successive degrees, which measures a growing intensity of life, corresponds to a higher tension of duration and is made manifest externally by a greater development of the sensory - motor system» (MM 296, Cf. also MM 332).

The funds crunch triggered by things as well as speedy credit score development, the regulatory deposit reserve prerequisite in addition to a crackdown on very hot dough inflows is abating subsequent to the central bank signaled its readiness to appease marketplace volatility.

In a letter dated Monday to Bart Schwartz, the investigator hired by the Executive Chamber to probe possible violations in upstate development contracts and grants, Beck's attorney Richard Pert addressed subsequent interactions between Beck and Howe.

In a bid to resolve the brewing tension orchestrated by Biafra agitations and the subsequent quit notice to Igbos, Arewa Youth Peace and Development Initiative and...

NKp46 was critical for the subsequent development of antiviral and antibacterial T cell responses, which suggests that the regulation of NK cell function by NKp46 allows for the optimal development of adaptive immune responses.

Cretins» prenatal development is disrupted by a lack of iodine and subsequent hypothyroidism, and they share many of the hobbit's traits, including short stature, argues Peter Obendorf of RMIT University in Melbourne, Australia.

As reported by Theodore Kotchen et al. and Howard Dickler et al. in The Journal of the American Medical Association in 2004 and 2007, respectively, about 40 % of M.D.s with K08 (mentored clinical scientist development) awards do not even apply for a subsequent first independent (R01) grant.

The degree to which this innate tendency to appreciate the taste of salt is modified by subsequent experience is a research area ripe for further investigation, particularly because high salt intake has been implicated in the development and / or maintenance of elevated blood pressure.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

Transition from vegetative to reproductive development was also observed by 11 DAS (Supplemental Figure 2E); however, subsequent developmental progression was delayed after 14 DAS in the mutant.

demonstrate that consumption of a peanut - containing snack by infants who are at high - risk for developing peanut allergy prevents the subsequent development of allergy.

The results of the Immune Tolerance Network's (ITN) «Learning Early About Peanut» (LEAP), discussed on February 23, 2015 at the American Academy of Allergy, Asthma & Immunology Annual Meeting and published in the New England Journal of Medicine, demonstrate that consumption of a peanut - containing snack by infants who are at high - risk for developing peanut allergy prevents the subsequent development of allergy.

As Head of Project Leader Unit, Nicolas is in charge of the pharmaceutical development and subsequent production of vaccines - for use in clinical trials - directly funded by the European Vaccine Initiative (EVI), and European projects funded from other sources coordinated by EVI.

«The findings suggest an effect of birth weight differences on development of subsequent conduct problems,» researchers led by Dr. David Mankuta of Hadassah Hebrew University Hospital in Jerusalem, said in a news release.

This current article is subject to the statistical errors as eloquently enumerated & discussed most recently by S Shapiro PhD (U of Capetown) regarding the UK «Million Women's Study»; about the use of postmenopausal hormones, the subsequent development of breast cancer, and the correct statistical approach.

The displacement of more nutrient - dense foods (eg, fruit, vegetables, lean meats, and seafood) by less - dense foods (refined sugars, grains, vegetable oils, and dairy products) and the subsequent decline in dietary vitamin and mineral density has far reaching health implications — consequences that not only promote the development of vitamin - deficiency diseases but also numerous infectious and chronic diseases (7).

The extensive review, and its subsequent presentation to 160 governments, led to the development of a multiyear Education Strategy published by UNHCR, which Dryden - Peterson helped to draft.

Prior to and subsequent to implementing the hybrid - block, there was significant discussion and teacher - driven professional development relating to how the additional time would be used by the teachers and students in order to optimize its positive impact on assessment tests, added Hagen.

The UN Secretary - General's subsequent Synthesis Report proposes one universal and transformative agenda for sustainable development, underpinned by rights, that is people - centred and planet - sensitive.

Any subsequent modification in the professional development team's recommendation to the board of education or BOCES shall be presented to the board of education or BOCES on or before June 1st, and the board of education or BOCES shall act on the plan by June 30th.

This gap between what teachers learn in pre-service education — and even in subsequent professional development courses — and what they need to know to use assessment effectively is the subject of a major initiative by NWEA.

Third, current pre-service teacher education and subsequent in - service professional development (PD) is characterised by very narrow conceptions about how teachers should teach — aided and abetted by the content of Australian State and Territory curriculum documents.

- The percentage of EL pupils who make progress toward English proficiency as measured by the California English Language Development Test (CELDT) or any subsequent assessment of English proficiency, as certified by the SBE.

For all Reading Recovery professionals, a full academic year of initial professional development is followed in subsequent years by ongoing support sessions.

Under development before Daewoo's bankruptcy, the Kalos was the company's first new model introduction following its subsequent takeover by General Motors.

Turbocharger technology was improved greatly by developments during World War II and subsequent development of the gas turbine.

This laid the foundation for many subsequent joint development projects, among them the 19 - inch Sport Classic wheel, offered by Porsche Tequipment as part of a limited production run of the same name.

Because of its quick success, Writers Digest Books published two subsequent writing books written by Larry and more are currently under current development.

We're disappointed by the subsequent lack of progress, and disturbed by a number of recent developments.

Subsequent changes may include the development of conjunctivitis, bacterial infection (often accompanied by a «thick» discharge), ulceration and, ultimately, blindness.

Avian veterinarians were initially excited by the discovery of avian bornavirus and the subsequent development of a commercial PCR test to identify it.

Dr. Mellersh performed the initial research (1,2) that provided information vital to the discovery of the Cord 1 gene mutation in English Springer Spaniels and the subsequent development of the test by Dr. Gary Johnson of the University of Missouri.

It is recommended that the Committee note the concerns raised by the ACHPR in their Communication 276 / 2003 in favour of the EWC, following EWC's complaint regarding the lack of recognition of their right to development, and in subsequent and related ACHPR resolutions concerning the World Heritage listing of Lake Bogoria, and urge the State Party to respond to ACHPR regarding these resolutions.

From tweaks and script edits still occurring this far in development to the fallout of THQ and the subsequent purchase by Ubisoft, a purchase South... Continue reading South Park Release Date and Trailer

Borchardt - Hume argues that subsequent developments in art make mid-70s projects such as the Jammers, inspired by Indian textiles, and Rauschenberg's later works on metal, easier to appreciate in retrospect.

Ranging across Jasper Johns's entire career — from his breakthrough paintings of the 1950's, which paved the way for the subsequent development of pop art and minimalism, Jasper Johns has had numerous museum retrospectives throughout his career, including paintings, drawings, prints as well as a host of other themes; recent highlights include the landmark 1997 exhibition» «Jasper Johns: A Retrospective» at the Museum of Modern Art, curated by Kirk Varnedoe and the breathtaking 2008 «Jasper Johns: Gray» at the Art Institute of Chicago and The Metropolitan Museum of Art.

They will be showing a range of work from a splendid measured drawing of a Corinthian column by Francis Terry, influenced by one of Palladio's drawings in his Quattro Libri, to models and drawings of projects and built work affirming Palladio's importance in the development of subsequent British architecture, especially the country house, with contemporary examples by Quinlan Terry, Julian Bicknell, John Simpson and Robert Adam Architects.

's importance in the development of subsequent British architecture, especially the country house, with contemporary examples by Quinlan Terry, Julian Bicknell, John Simpson and Robert Adam Architects.

By the mid-1920s, the importance of cubism for American artists was in decline, but the movement was the stepping - off point for the subsequent development of American abstract art.