Not exact matches
Geoff Hinton, a leading neural networking theorist, argues the hardware is useless without the proper «learning algorithm» spelling out which factors change the strength of the
synaptic connections and
by how much.
The long - term facilitation of
synaptic efficacy that is induced
by serotonin in dissociated cell cultures of sensory and motor neurons of Aplysia is accompanied
by the growth of new
synaptic connections.
Instead, the molecular processes triggered
by memory formation and recall could reflect the stabilization of previously altered or recently retrieved
synaptic connections.
Over-activation of the D2 class of dopamine receptors led to suppression of the function of NMDA receptors, which are activated
by the neurotransmitter glutamate, at the
synaptic connection between hippocampus and prefrontal cortex.
Building on their previous work that identified and activated memory cells, a group led
by RIKEN Brain Science Institute and RIKEN - MIT Center Director Susumu Tonegawa has now shown that spines — small knobs on brain - cell dendrites through which
synaptic connections are formed — are essential for memory retrieval in these AD mice.
Animal behaviour arises from computations in neuronal circuits, but our understanding of these computations has been frustrated
by the lack of detailed
synaptic connection maps, or connectomes.
When the researchers modeled the effects in mice, they found it strengthened the
connections between neurons that make learning possible — what is known as
synaptic plasticity —
by increasing the action of a cell receptor critical to forming memories.
They are exploring whether these developmental findings can be used to address diseases such as stroke,
by promoting the repair of
synaptic connections following injury.
Additionally, the complement system acts in brain development to refine
synaptic connections by removing those that are weak or misdirected.
This will allow for the capture of all the
synaptic connections between individual neurons at small targeted regions guided
by the X-ray microtomography.