Sentences with phrase «by synergistic effect»

Not exact matches

The study found that carfilzomib and irinotecan have a potential synergistic effect in SCLC and other Irinotecan - sensitive cancers by allowing normal DNA damage repair and enabling normal cell - cycle death.

Interference with a host of cellular functions tested and synergistic activities with a wide range of other drugs is best explained by direct interaction with various DNA sequences and general interference with replication and transcription, except for some effects exerted by binding to tubulin.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Synergistic enhancement of the anti-cancer effects of naringenin can be obtained by combining it with either curcumin83 or vitamin E, 84 and one study reports that nano - encapsulated naringenin exhibits «significantly higher» antioxidant and anticancer properties than naringenin in free form.86

Tango Advanced Nutrition's herbal formulas are based exclusively on Tonic Herbalism — the practice of combining traditional tonic herbs to achieve a synergistic effect greater than what can be obtained by taking individual herbs.

Regular consumption of both green tea and foods rich in lycopene resulted in a synergistic protective effect, stronger than the protection afforded by either, the researchers also noted.

Tango Advanced Nutrition's herbal formulas are based exclusively on Tonic Herbalism — the practice of combining traditional «tonic herbs» into formulas that offer a synergistic effect far greater than that possible by taking individual herbs.

These heating, metabolism charging spices have a synergistic effect that will increase the bioavailability by 1,000 times.

Therefore mitigating global warming will address both the synergistic harm that it wreaks in concert with the non-climate damage to the environment, and it will address the direct effect that it will have on species and ecosystem - an effect that, if warming is not properly addressed for a few more decades, will make all other human impacts pale by comparison.

Elevating pCO2 concentration and shifting nitrogen source have a synergistic effect on calcification [24], and here we indicate that the responses of E. huxleyi to elevated pCO2 might be offset by simultaneously increasing temperature.

By implementing long term and short term strategies together, you will see a synergistic effect that is greater than the sum of its parts.