Sentences with phrase «by synthetic cell»

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They'd be transformed by synthetic biology, a young field of engineering that crafts building materials from DNA and cells rather than more traditional biological materials, like trees.

By repeatedly introducing a pool of synthetic DNA to the cells, a huge variety of strains can be...

Kilian said his team's synthetic microenvironment lies somewhere in the middle of two extremes in the field of modeling biology: the hard plastic plate, and expensive mouse avatars that are created by injecting human tumor cells into mice.

«Tumble - proof cargo transporter in biological cells: New model shows how collective transport by synthetic nanomotors along biopolymer filaments can be effectively directed.»

Engineers developed the first tiny, synthetic machines that can swim by themselves, powered by beating heart cells.

The new study shows that the synthetic compound is capable of inhibiting the activities of several DNA - processing enzymes, including the «integrase» used by the Human Immunodeficiency Virus (HIV) to insert its genome into that of its host cell.

The startling feat prompted President Barack Obama to ask his newly formed bioethics commission to examine the implications of the Venter study and other kinds of synthetic biology, such as creating biological circuits by putting components together in a cell.

As a step toward propagation of synthetic genomes, we completely replaced the genome of a bacterial cell with one from another species by transplanting a whole genome as naked DNA.

Modeled after platelets — cells that circulate in the blood and help stop bleeding by forming clots — the nanoparticles are less than 100 nm wide and made of synthetic polymers stuck together like a ball of wet sand.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

The synthetic hydrogel had disappeared, replaced by natural extracellular matrix produced by the cells themselves.

The synthetic poliovirus cDNA was transcribed by RNA polymerase into viral RNA, which translated and replicated in a cell - free extract, resulting in the de novo synthesis of infectious poliovirus.

It also offers an alternative to the approach used by biologist Craig Venter of building a genome from scratch to impart new properties to cells — laborious because even the smallest error kills the cell (see «Craig Venter: Why I put my name in synthetic genomes «-RRB-.

Powered by the synthetic genome, that microbial cell began replicating and making a new set of proteins.

We report the design, synthesis, and assembly of the 1.08 — mega — base pair Mycoplasma mycoides JCVI - syn 1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are controlled only by the synthetic chromosome.

Obama called for the study in May after a team led by biologist J. Craig Venter reported that it had inserted a synthetic genome into a self - replicating cell.

Purdue University researchers have shown that a synthetic version of a high - strength adhesive produced by mussels is non-toxic to living cells, suggesting its potential suitability for surgical and other biomedical applications.

Craig Venter and his teams at the J. Craig Venter Institute in Rockville, Maryland, and San Diego, California, have shown themselves to be technical wizards by synthesising a genome from code contained on a computer, and using it to start a cell line of the resulting synthetic organism (see «How the synthetic bacterium was made»).

Scientists today announced that they have crafted a bacterial genome from scratch, moving one step closer to creating entirely synthetic life forms — living cells designed and built by humans to carry out a diverse set of tasks ranging from manufacturing biofuels to sequestering carbon dioxide.

The point mutation was induced by forming a synthetic complex through removal of nuclease activity from the CRISPR system — a technique using artificial nuclease — and addition of deaminase, a deaminizing (base - modifying) enzyme, and then expressing it in yeasts and mammalian cells.

By designing synthetic proteins that can only interact with a pre-determined partner, and introducing them into cells, the team revealed a key interaction that regulates the ability of embryonic stem cells to change into other cell types.

Now, in a new study published in the journal Cell, scientists at the Salk Institute for Biological Studies have discovered that a synthetic form of vitamin D, calcipotriol (a drug already approved by the FDA for the treatment of psoriasis), deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for fibrotic diseases in humans.

By transferring the gene for melanopsin into human embryonic kidney cells, synthetic biologist Martin Fussenegger of the Swiss Federal Institute of Technology in Zurich and colleagues made these cells light - sensitive as well.

His laboratory currently applies high throughput imaging technologies to study trafficking between the endoplasmic reticulum and Golgi complex, and the internalization pathways taken by synthetic nanoparticles on exposure to cells.

But by the time the meeting was held, the name had been changed to «HGP - Write: Testing Large Synthetic Genomes in Cells.»

In the group of mice treated with synthetic IAPP aggregates, we observed a substantial reduction in the area of islets occupied by β cells as compared with controls untreated or treated with the same concentration of nonaggregated IAPP (Fig. 7 D).

Defective HR is an important therapeutic target in EOC as exemplified by the efficacy of platinum analogues in this disease, as well as the advent of PARP inhibitors, which exhibit synthetic lethality when applied to HR - deficient cells.

Mukherji B, Chakraborty NG, Yamasaki S, Okino T, Yamase H, Sporn JR, Kurtzman SK, Ergin MT, Ozols J, Meehan J, Mauri F. Induction of antigen - specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide - pulsed autologous antigen presenting cells.

Gianneschi and his team found that the synthetic melanin nanoparticles in their experiments were not only absorbed and distributed normally by the keratinocytes in the epidermis, but they also protected human skin cells from UV radiation damage.

LA JOLLA — A synthetic derivative of vitamin D was found by Salk Institute researchers to collapse the barrier of cells shielding pancreatic tumors, making this seemingly impenetrable cancer much more susceptible to therapeutic drugs.

We are seeking individuals to characterize novel synthetic inhibitors developed by our collaborators in vitro and in cell culture (the latter for effects on peptide hormone / neurotransmitter) synthesis).

This cell line was generated by co-transfection of HeLa cells with pSV2neo and with pL3tat, which contains the HIV - 1 LTR promoter, synthetic first tat exo

We propose a system of synthetic bio cementing where engineered cells, living within a soil matrix, respond to pore pressure changes in their environment when the soil is loaded, by synthesizing new material and strengthening the soil.

On May 20th of this year, researchers at the J.C. Venter Institute announced the creation of a bacterial cell controlled by a synthesized genome, a significant milestone in the emerging field of synthetic biology.

The well - established core capabilities in high throughput RNAi and multi-parametric microscopy assays have yielded optimized protocols in a broad and ever - growing collection of cultured human and rodent cells, and are now complemented by microRNA - focused experimentation and in vivo applications of synthetic siRNAs.

CAR therapy works by genetically modifying a person's own T - cells to express a synthetic receptor that allows cancer cell recognition.

Sc2.0 is the first step towards a future that undoubtedly includes cells powered by synthetic chromosomes and / or genomes.

A recent study led by BSI member Professor Andrew Sewell from Cardiff University and published in the Journal of Clinical Investigation showed that a synthetic «mirror image» version of a protein belonging to the influenza A virus generated strong immune responses in human cells and mice, with the mice also being protected when exposed to a strain of influenza A.

This joint venture, funded by the European Research Council, EPSRC and NPL's Strategic Research Programme, is a rare blend of interdisciplinary research bringing together expertise in robotics, haptics and machine vision with synthetic and cell biology, protein design, and super - and high - resolution microscopy.

Interestingly, alterations in these un-druggable genes distinguish cancer cells from normal cells, conferring «synthetic lethal» vulnerabilities that can be exploited by novel targeted therapies.

We challenge the mutual interdependence of lipid - protein interactions by an interdisciplinary approach, combining cell biology and synthetic biology as well as protein biochemistry, structure biology and biophysics.

Through synthetic viability screening, we discovered that histone H4 K16 deacetylation drives the sensitivity of yeast cells to camptothecin and that inactivation of this pathway by mutating H4 K16 or the genes SIR1 - 4 suppresses much of the hypersensitivity of tof1 ∆ strains towards this agent.

Keiichiro Suzuki, a CRISPR expert from Salk Institute researcher, also not involved in the study, said by email: «Due to the high stability, specificity and ease for biosynthesis, the synthetic CRISPR RNA approach developed in this study will facilitate targeted genetic modification in a variety of human cells for fundamental studies as well as therapeutic applications»

The featured lung cancer study, for instance, not only used synthetic vitamin E (tocopheryl) but also neglected to include any tocotrienols, which have previously been shown to kill cancer stem cells, the most malignant of all cells with a tumor.5 As noted by Dr. Andrew Saul, the study was set up to fail: 6

Dienogest, a synthetic progestin, inhibits prostaglandin E (2) production and aromatase expression by human endometrial epithelial cells in a spheroid culture system..

The latest achievement of J. Craig Venter — rebooting a bacterial cell as a different species by giving it a man - made genetic instruction manual — is just one step on the long inevitable path into synthetic biology.

The researchers are not discourage by this though because the algae - based cell has many advantages over synthetic version.

Indeed, it appears that researchers in Australia did just that last year by developing what they called «3 - D replacement skin» which combines «stem cells with synthetic materials like collagen, elastin and other products.»