Sc2.0 is the first step towards a future that undoubtedly includes cells powered
by synthetic chromosomes and / or genomes.
We report the design, synthesis, and assembly of the 1.08 — mega — base pair Mycoplasma mycoides JCVI - syn 1.0 genome starting from digitized genome sequence information and its transplantation into a M. capricolum recipient cell to create new M. mycoides cells that are controlled only
by the synthetic chromosome.
Not exact matches
The study was made possible
by our unique
synthetic chromosome system, which allowed us to study the structure and maintenance of centromeres in remarkable detail.»
Base pairs that exist only in the lab, rearranged
chromosomes, even entire
synthetic genomes — all have been made
by scientists in recent years.
In 2003, scientists at the J. Craig Venter Institute (JCVI) led
by Drs. Smith, Hutchinson and Venter, built in vitro a fully
synthetic PhiX174
chromosome in just 14 days and published their results in the Proceedings of the National Academy of Sciences.
Completing this massive project, which is led
by some of the authors of this study along with their collaborators around the world, will require many mating - type switches to consolidate the final
synthetic chromosomes in a single strain.