Sentences with phrase «by systems biology»

These hard puzzles can only be solved by systems biology, proponents say.

Not exact matches

«The forms of a living being are not but rather come to be,» says Ludwig von Bertalanffy (BW 120), and his «organismic» biology and later general system - theory for overcoming the opposition between mechanism and vitalism has given central insights of Whitehead a new formulation on the basis of science, 8 Something similar holds for all the directions of research which Jean Piaget has brought to the [264] concept of genetic structuralism.9 The genetic epistemology founded by Piaget has proved through empirical research on the problem of knowledge the fruitfulness both of genetic analysis and of Whitehead's principle of process.

Waddington's paper in Towards a Theoretical Biology follows on from one by Brian Goodwin («A Statistical Mechanics of Temporal Organization in Cells») in which Goodwin looks at the question of how ordered systems like cells, and still more macro-organisms, supervene on the movements of their constituent molecules, and how one is to close the gap between molecular biology and cell physiology.

SOGI policies attempt to impose, by force of law, a system of orthodoxy with respect to human sexuality: the belief that marriage is merely a union of consenting adults, regardless of biology, and that one can be male, female, none, or both, again, regardless of biology.

These are the ideas which were first brought forward in biology by thinkers such as Needham and Woodger (with myself acquiescing on the side - lines) under the name «Organizing Relations,» and by Bertalanffy, who conducted a vigorous propaganda campaign on their behalf, under the name of «Systems Theory, and finally by Norbert Wiener, with equal fervour, as «Cybernetics.»

Not that that's necessarily the very first way Darwinian systems began, but at some point they had to transition into a system more related to modern biology where cells are all bounded by membranes.

The agency supports network science through individual institutes (for example, the National Institute of General Medical Sciences funds nine National Centers for Systems Biology, academic centers that emphasize network biology) and through agencywide initiatives (such as the National Technology Centers for Networks and Pathways, funded by the NIH Roadmap for Medical Research and the recently announced Human Connectome Project, which aims to map the connections among the human brain's 100 billion neurons).

Peng Yin, a systems biologist at Harvard University, who was not involved in the new research, says he is impressed by the work and calls it «an important advance for molecular programming, dynamic DNA nanotechnology and in vitro synthetic biology.»

Working with colleagues at the Center for Theoretical Biological Physics at the University of California, San Diego, he wants to unravel what it is that makes bacteria so adept at survival by looking at pattern formation in complex dynamic systems alongside the molecular biology and biophysics of bacteria.

My cancer systems biology team at the University of California, Merced, is tackling diagnosis and treatment of therapy - resistant cancers by elucidating the network of changes within cells as a way to identify new drug targets and circumvent cancer resistance.

I realize that your «Working Group On Review Of Bioengineering And Technology And Instrumentation Development Research», defined «bioengineering and technology» as encompassing areas such as biotechnology, functional genomics, informatics, chemistry and physics, nevertheless they did not discuss the problems experienced by physicists engaged in basic research on the frontier of physics and biology from the present system of study sections.

By fitting DNA into an engineering template, the messy field of biology emerges as a complex but somewhat predictable system — one that synthetic biologists have begun to maneuver in recent years.

For example, among the latest EMBL selection for the international Ph.D. program, there are quite a few students of biology who financed their studies by working as system managers or software developers, i.e., with the right kind of general background.

The St. Laurent Institute, a non-profit medical research institute focused on the systems biology of disease, today announced in a study published in the July edition of Genome Biology, that genetic matter, previously ignored by the scientific community, may play an important role in cancer.

Undergraduate Sophia Hsing - Jung Li is excited by this new field of «systems biology.»

More recently, reductionism has been counterbalanced by the emergence of «systems biology,» which I expect to reanimate the crucial link between basic science, clinical research, and medical practice.

His research group focuses on big data network biology, exploring biological systems by developing and deploying algorithms aimed to predict cell behavior, in particular looking at cellular signal processing and decision making.

«But it doesn't matter because the way that we're trying to build systems biology is by bringing together pillars of expertise and letting the osmosis between them generate something new.»

Systems biology is just starting to be recognized by federal and provincial granting councils, says Figeys.

The new research recently published by scientists at the Okinawa Institute of Science and Technology Graduate University (OIST) in the journal Soft Matter carefully examines the relationships between self - motile and passive or inert agents to determine possibility of creating fully synthetic systems by looking into examples of biology interacting with mechanical mechanisms.

Lead author Aaron Allen was a PhD student in cell & systems biology at U of T when the work was done, and he was assisted by Sokolowski, fellow EEB student Ina Anreiter, and Oxford University collaborator Megan Neville, who taught Allen the technique.

In recent years, the study of human biology has been shaken up by discoveries of how the bacteria that live in the gut, the so - called microbiome, affect metabolism, the immune system, and disease progression.

The approach combined experimental synthetic biology led by Mark Isalan, now Reader in Gene Network Engineering at the Department of Life Sciences of Imperial College London with computational modelling led by James Sharpe, ICREA Research Professor and head of the Multicellular Systems Biology lab at the CRG.

If life today is the result of evolution by natural selection, Darwin realized, then even the most complex systems in biology must have emerged gradually from simple precursors, like someone crossing a river using stepping - stones.

By using a systems biology approach, researchers deliberately move away from the classic reductionist manner of looking at molecules in isolation to study biological systems in their entirety.

The research missions include a microbiology study of yeast, a fruit fly study designed and built by students, a plant biology investigation and the maiden voyage of NASA's new rodent research system.

So it could be RNA or DNA like we have in modern biology or it could be some related kind of material; and we are also thinking about some kind of cell envelope or cell membrane — not that that's necessarily the very first way Darwinian systems began, but at some point they had to transition into a system more related to modern biology where cells are all bounded by membranes — so we're thinking about how to assemble these two components and get them to interact with each other.

«We continue to be fascinated by the functions of bacterial CRISPR systems and how mechanistic understanding leads to opportunities for new technologies,» said Doudna, a professor of molecular and cell biology and of chemistry and a Howard Hughes Medical Institute investigator.

The research group, led by Erika Matunis, Ph.D., a professor of cell biology at the Johns Hopkins University School of Medicine, has been using the fruit fly as a model living system in which to study stem cells in their natural state.

«Earlier studies have shown that vitamin E can help regulate the aging body's immune system, but our present research is the first study to demonstrate that dietary vitamin E regulates neutrophil entry into the lungs in mice, and so dramatically reduces inflammation, and helps fight off infection by this common type of bacteria,» said first author Elsa N. Bou Ghanem, Ph.D., postdoctoral scholar in the department of molecular biology and microbiology at Tufts University School of Medicine (TUSM).

Pedler, a marine biology graduate student at Scripps, spent several years working with Scripps marine microbiologist Azam and chemical oceanographer Aluwihare in designing a system that would precisely measure carbon consumption by individual bacterial species.

We use a combination of genomics, systems biology, biochemistry, bioinformatics and molecular biology to investigate the networks formed by RNA binding proteins, miRNAs and their target genes and evaluate their impact on biological processes, cancer and disease states.

Jaleel Miyan, a neurobiologist at the University of Manchester in England who did not participate in this research, stressed the significance of this finding by characterizing the analogy with the lymphatic system as inadequate: «What they have demonstrated is actually far more extensive and important to CSF [cerebrospinal fluid] biology.»

To achieve such integration, Tara Oceans is driven by researchers with expertise in biological and physical oceanography, ecology, microbiology, systematics, molecular, cellular and systems biology, bioinformatics, data management, and modeling.

This technology has begun to revolutionize biology by providing a new application for functional genomics in experimental systems.

My goal is to contribute to the resolution of this important problem by bringing to bear recent advances in human genetics and integrative genomics and translating them in a mechanistic, systems - level understanding of disease that is rooted in human biology but also actionable from a drug development perspective.

Caribou's technologies are based on research into the biology of CRISPR - Cas systems carried out by the Doudna Lab at the University of California, Berkeley, and their collaborators.

We have been studying endocytosis in a broader, systems perspective, by combining quantitative imaging, genome - wide RNAi screens with systems biology analysis.

This two - volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system.

Sex differences describe biology - linked differences between women and men, which are caused by differences in sex chromosomes, sex - specific gene expression of autosomes, sex hormones, and their effects on organ systems (Figure 1)(1, 3).

Further, none of these previous studies took a systems biology approach by examining covariation across GE patterns (versus specific gene pathways).

Approaches successful in other systems, such as modeling signal transduction and synthetic biology methodologies [32] could improve future generations of detector plants by enhancing signal transmission and providing means to deal with biological «noise».

Systems - biology studies have mapped out aging - related genetic networks, but these top - down approaches are complicated by the difficulty of distinguishing correlations from causality.

Systems biology aims to study complex cellular systems by systematically stimulating them, monitoring cellular responses, formulating mathematical and computational models to understand the data, and proposing new experiments to refine these Systems biology aims to study complex cellular systems by systematically stimulating them, monitoring cellular responses, formulating mathematical and computational models to understand the data, and proposing new experiments to refine these systems by systematically stimulating them, monitoring cellular responses, formulating mathematical and computational models to understand the data, and proposing new experiments to refine these models.

The AgedBrainSYSBIO consortium is coordinated by the French National Institute for health and medical research (Inserm, Prof. Michel Simonneau) and brings together an scientists with internationally recognized expertise in systems biology of the synapse and four small to medium size enterprises (SMEs) with a leading role in the project to assure the innovation potential and translation of project results to clinical application.

In Entamoeba invadens, stage conversion can be induced, but its utility as a model system to study developmental biology has been limited by a lack of genomic resources.

The stellar classification system is taxonomic, based on type specimens, similar to classification of species in biology: The categories are defined by one or more standard stars for each category and sub-category, with an associated description of the distinguishing features.

Our global aim is to reconstruct such networks by focusing on individual components (cells, soluble factors, membrane receptors), or by integrating multiple components using systems biology and modeling.

SYSCOL — Systems biology of colorectal cancer — is a collaborative project financed by the EU Framework Programme 7.

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels