Moreover, in some cases, pancreatic cancer cells can even repair damage to their DNA caused
by the chemotherapy drugs that do get into the tumor, further protecting themselves.
Linking the differentiation process with organ - on - a-chip technology pioneered by his team, the researchers went on to engineer the first in vitro model of the human glomerulus, demonstrating effective and selective filtration of blood proteins and podocyte toxicity induced
by a chemotherapy drug in vitro.
Not exact matches
Those
drugs in combination reduce patients «risk of death or their cancer progressing
by 42 percent versus
chemotherapy, still beating Wall Street «s estimates.
For instance, most common adult solid tumors that are not cured
by surgical removal are resistant to
chemotherapy or radiation control, yet
drug therapy is frequently offered as a «possibly effective» treatment because both patient and physician want to believe it so.
Another study from Nigeria published in December of 2017 is titled Antioxidant and anti-inflammatory effects of virgin coconut oil supplementation abrogate acute
chemotherapy oxidative nephrotoxicity induced
by anticancer
drug methotrexate in rats.
Breastfeeding after
chemotherapy has been completed may be possible, either
by relactation or as a result of another pregnancy, depending upon the
drugs that were used.
Chemotherapy (
drug treatment) was later developed to destroy small tumour growths that were not treatable
by other methods.
One of those licenses went to Michael Hackett, a UNC doctoral student who got an idea 2 years ago for a potential commercial
drug: to trick tumors into absorbing
chemotherapy drugs by designing a molecular Trojan horse.
Doxorubicin is a
chemotherapy drug used to treat a wide range of cancers
by preventing cancer cells from replicating.
Chemotherapy drugs designed to kill tumors may actually encourage ovarian cancer
by stimulating the growth of cells that give rise to the malignancy, a new study finds.
So far there's no approved
drug on the market that reverses cancer
chemotherapy resistance caused
by P - glycoprotein, or P - gp for short, said Vogel, a biochemistry professor at SMU.
McKenna and his team have identified four different
drugs — including the anti-HIV
drug nelfinavir — that can disrupt the process
by which hypoxia occurs, restoring proper blood flow to the tumours and making them more vulnerable to
chemotherapy (Cancer Research, DOI: 10.1158 / 0008 - 5472.
That injection puts the «gas on» the immune system followed
by a second injection of a
drug being developed as a
chemotherapy.
Potti and his colleagues began
by testing
chemotherapy drugs on cultured cell lines from human tumors, such as from the lung, breast, or ovary.
«
By administering
chemotherapy within this «therapeutic window,» oncologists could apply a lower dose of
chemotherapy drugs to patients, with the potential for an improved treatment outcome — all while minimizing
drug toxicity to healthy organs,» He said.
Chemotherapy drugs are often designed to kill off malignant cells
by damaging their DNA until they transition to a programmed death mode called apoptosis.
In one example highlighted
by the researchers, mouse models of T - ALL were treated either with a combination of mTOR inhibitor pp242 and the
chemotherapy drug AraC, or they were treated with just AraC or pp242.
«In pancreatic, ovarian and liver cancers, we hope that
by adding anti-cancer stem cell
drugs to standard of care, we can control proliferating cells within the tumor that could otherwise help the tumor regenerate in the face of existing
chemotherapies.»
Most cancer
chemotherapy relies on cells absorbing
drugs by diffusion across the cell membrane.
A team of researchers led
by Dr. Jian Zuo screened over 4,000
drugs for their ability to protect cochlear cells from the
chemotherapy agent cisplatin.
The findings, announced online in the journal Antimicrobial Agents and
Chemotherapy and funded
by the National Institutes of Health, provide a needed boost to the field of antibiotic development, which has been limited in the last four decades and outpaced
by the rise of
drug - resistant bacterial strains.
An early - stage clinical study
by another institution, published in the Lancet Oncology in May 2016, combined
chemotherapy with an experimental
drug that blocks CCR2, a receptor on monocytes and macrophages whose activation stimulates these cells to infiltrate tumors.
Potential cancer treatments are loitering in the wings as clinical trials are delayed
by widespread shortages of common
chemotherapy drugs.
By kick - starting a gene that is naturally inactivated,
chemotherapy drugs could help reverse a genetic brain disorder that is sometimes mistaken for autism or cerebral palsy.
But a new study reports that these tiny flecks of carbon can shrink tumors in mice
by delivering
chemotherapy drugs to cancer cells.
As part of the project, announced last week
by Kenneth Hagemann, director of the Pentagon's Defense Nuclear Agency, 24 soldiers from Brooks Air Force Base in Texas are taking prescription
drugs — ondansetron hydrochloride and granisetron hydrochloride — that are given to cancer patients undergoing radiotherapy or
chemotherapy.
«
Drug could limit spread of deadly brain tumors: Study shows PPF could help treat glioblastomas
by sensitizing tumors to
chemotherapy, radiation treatments.»
A
drug used to treat men with late - stage prostate cancer proved effective in stemming progression of the disease in research participants who had not yet received
chemotherapy and extended their survival, according to results from a multi-national Phase III clinical trial led
by the Knight Cancer Institute at Oregon Health & Science University (OHSU).
A phase I clinical trial conducted
by investigators at the University of Texas San Antonio, showed that the combination of HCQ and the
chemotherapy drug vorinostat in 27 patients with advanced solid tumors, including renal cell carcinoma and colon cancer, was clinically safe and inhibited autophagy.
A
drug recently developed
by Pfizer, crizotinib, targets ALK and is currently given to patients with ALK positive lung cancer when their cancer has worsened after initial
chemotherapy.
Enzalutamide, which is taken as four pills once per day, is already approved
by the Food and
Drug Administration (FDA) for men whose disease has not been stopped
by other treatments including, surgery, radiation, androgen deprivation therapy and
chemotherapy.
The
chemotherapy drug bortezomib (marketed
by Millennium Pharmaceuticals under the brand name Velcade) takes advantage of this reliance and targets the proteasome's function.
Dronabinol was approved
by the Food and
Drug Administration more than 25 years ago to treat nausea and vomiting in
chemotherapy patients.
The researchers then exposed cells from each of these lines to a panel of 31 different
drug treatments — including 23
chemotherapy compounds approved
by the FDA for breast and ovarian cancers, six targeted cancer
drugs, and two common
drug combinations.
«Since 95 percent of cancer patients still get chemo, we realized we could make a major impact on cancer treatment
by helping clinicians prescribe the right
chemotherapy drug,» said Sourav Bandyopadhyay, PhD, a professor of bioengineering and therapeutic sciences in UCSF's Schools of Pharmacy and Medicine and senior author on the new study.
By controlling the timing of the interaction, researchers could pinpoint delivery of the
drug to a precise location, thus preventing side common side effects of
chemotherapy, such as hair loss or cardiac toxicity.
As part of the new study, the researchers showed that intact axons without Phr1 were protected from the damage caused
by vincristine, a
chemotherapy drug used to treat leukemia, neuroblastoma, Hodgkin's disease and non-Hodgkin's lymphoma, among other cancers.
By contrast, a signal of tumor activity increased sixty-fold in mice treated with the widely used
chemotherapy drug gemcitabine.
He published another study in August 2015, showing that resistance to the
chemotherapy drug doxorubicin is likewise increased
by ALAN.
They confirmed this
by showing that tumor growth was reduced in mice treated with an antibody
drug that targets TIM - 3 and the
chemotherapy agent paclitaxel, as compared to treatment with paclitaxel alone.
This study, conducted
by the Gynecologic Oncology Group, a cooperative group funded
by the National Cancer Institute, was the second to test bevacizumab under these conditions (first
chemotherapy for platinum - sensitive recurrence), a use for which bevacizumab is not currently approved
by the Food and
Drug Administration.
The study
by researchers at King's College Hospital and the University of Southampton suggests that adding nutraceuticals to
chemotherapy cycles may improve the effectiveness of conventional
drugs, particularly in hard to treat cancers, such as pancreatic cancer.
The
drug, birinapant, sensitizes the CA125 - negative cells to the
chemotherapy by restoring apoptosis, or programmed cell death, said Dr. Sanaz Memarzadeh, a senior author of the study and a UCLA gynecologic cancer surgeon.
The period of time before ovarian cancer recurred (called progression - free survival) improved
by nearly 3.5 months with the additional
drug (13.8 months compared with 10.4 months for the woman on
chemotherapy alone).
In animal studies and early clinical trials, the
drug known as Epo (for erythropoietin) appeared to counteract anemia caused
by radiation and
chemotherapy.
They analyzed the association between body mass index (weight divided
by height) and progression - free survival (PFS) and overall survival (OS) in six independent cohorts of patients treated with targeted therapy, immunotherapy or
chemotherapy in pivotal trials that led to FDA approval of these
drugs.
Brenneman benefited from her colleagues» support during the 2 years she was weakened
by chemotherapy and
drug treatments.
A similar antibody -
drug conjugate approach is used
by the breast cancer agent T - DM1, which attaches
chemotherapy to an antibody that seeks the HER2 protein in HER2 + breast cancers.
NEW HOPE AGAINST RESISTANT BREAST CANCER: Ixabepilone, a compound being investigated
by Bristol - Myers Squibb, shows some encouraging effectiveness against metastatic breast cancers that are resistant to three other standard
chemotherapy drugs (anthracycline, taxane and capecitabine).
This therapeutic effect was enhanced
by combining the Angiopoietin - 2 antibody with a so - called metronomic
chemotherapy: In this kind of therapy, chemotherapeutic
drugs are given continuously at much lower dose as in the classical high - dose
chemotherapy.