Sentences with phrase «by the leptin receptor»

Leptin circulates in the blood and crosses into the brain, where it is sensed by leptin receptors expressed on neurons in the hypothalamus.

I've mentioned previously JAK2 is the kinase that's activated by the leptin receptor, and that leads to recruitment and activation of the STAT3.

Not exact matches

Van Blerkom had been seeing hints of polarity since the 1970s, but one of the major turning points occurred in 1996 when, by accident, his lab discovered that cells surrounding the developing egg — the same granulosa cells that had piqued Albertini's interest — possessed a receptor very similar to the leptin receptor.

Impaired Ca2 + Signaling in β - Cells Lacking Leptin Receptors by Cre - loxP Recombination.

In order to improve culture conditions for maturation of cumulus - free oocytes in vitro, we began by assaying the expression of 15 growth factors (BDNF, IGF - I, estradiol, GDNF, leptin, FGF1, FGF2, GM - CSF, EGF, TGF - α, TGF - β1; 2; 3, and ET - 1; 2) and 27 of their cognate receptors that have been shown to regulate oocyte maturation.

In addition, the chronic elevation of cortisol levels caused by excessive stress negatively affects the receptors for both insulin and leptin, which makes it harder for the body to read the signals of those hormones, thus keeping fat trapped in the cells and making you hungry all the time.

✓ Endocrine disruption: WGA may contribute to weight gain, insulin resistance and leptin resistance by blocking the leptin receptor in your hypothalamus.

Insulin and leptin receptor resistance from too many net carbs and activation of the mTOR metabolic signaling pathway by too much protein.

By increasing your insulin and leptin levels (and subsequently decreasing receptor sensitivity for both of these vital hormones), excessive sugar / fructose consumption not only increases your risk of type 2 diabetes, it also accelerates aging in general.

In a 2007 study conducted by the Joslin Diabetes Center, mice were genetically engineered to not have the necessary leptin receptors in the pancreas.

Leptin is secreted by fat cells and is received by receptors in the hypothalamus.

Chronic overfeeding and carbohydrate consumption up and above what is needed by the body causes leptin receptors to become resistant.

✓ Disrupts Endocrine Function — WGA may contribute to weight gain, insulin resistance, and leptin resistance by blocking the leptin receptor in your hypothalamus.

For example, fiber is metabolized by our gut flora into short - chain fatty acids, which bind to and activate receptors on the surface of our cells that alter our metabolism, for example, activating receptors on fat cells to increase the expression of the weight - reducing hormone, leptin.