Sentences with phrase «by the parasite trypanosoma»

Chagas disease is caused by the parasite Trypanosoma cruzi, which, in different forms, infects both humans and insects.

Not exact matches

Using a combination of human or specially engineered mouse cells in vitro and in vivo animal models, study senior investigator Judy Lieberman, MD, PhD; study lead investigator Farokh Dotiwala, PhD, with a team lead by the Brazilian parasitologist Ricardo Gazzinelli, DSc, DVM, found that when an immune killer cell, such as a T - cell or natural killer (NK) cell, encounters a cell infected with any of three intracellular parasites (Trypanosoma cruzi, Toxoplasma gondii or Leishmania major), it releases three proteins that together kill both the parasite and the infected cell:

Sleeping sickness, caused by two subspecies of the Trypanosoma brucei unicellular parasite and transmitted by tsetse flies, affects an estimated 50,000 to 70,000 people annually in Africa.

They enrolled 280 patients in a trial that compared the standard eflornithine regimen with one in which only 14 infusions of that drug were given over a week's time, combined with 10 days of nifurtimox, an oral drug licensed against Chagas disease — which is also caused by Trypanosoma parasites — but not considered active enough as a standalone HAT drug.

Gambian sleeping sickness, or Gambian human African trypanosomiasis, is caused by a parasite called Trypanosoma brucei gambiense, carried by tsetse flies in Central and West Africa.

HAT is caused by a single - celled parasite, Trypanosoma brucei, that enters the body through the bites of tsetse flies.

In more current, but not yet published work, Sattler is also fusing NMR and crystallography in a drug discovery project to find small molecule inhibitors that neutralize trypanosoma, parasites that cause sleeping sickness, by disrupting life - critical protein - protein interactions.

According to the Centers for Disease Control and Prevention, millions of Americans are affected by parasite infections every year; from the 300,000 people — many unknowingly — infected with Trypanosoma cruzi, which causes Chagas disease, to the estimated 1.1 million new Trichomonas infections each year.

The team, led by Dr. Carter, examined where the geographic range of a Trypanosoma parasite will shift by 2050 under two possible climate scenarios: moderate climate change mitigation and business - as - usual.