Sentences with phrase «by this fusion gene»

In their previous study, the researchers found that drugs that inhibit FGFR3 kinase, an enzyme that helps the protein produced by this fusion gene do its work, increased survival when tested in mice with glioblastoma.

Not exact matches

Such methods include cell fusion, microencapsulation and macroencapsulation, and recombinant DNA technology (including gene deletion, gene doubling, introducing a foreign gene, and changing the positions of genes when achieved by recombinant DNA technology).»

This microscopic image of fibroblast cells shows the induction of cell fusion by a newly described gene and its protein, called myomerger.

Researchers then tested cell cultures and mouse models by using a gene editing process called CRISPR - Cas9 to demonstrate how the presence or absence of myomaker and myomerger — both individually and in unison — affect cell fusion and muscle formation.

Subsequent procedures included mammalian somatic cell nuclear transfer, cell fusion, induction of pluripotency by ectopic gene expression, and direct reprogramming.

In fact, there are two specific mechanisms for activation of BRAF implicated in PA formation: by fusion of the gene with nearby gene KIAA1549 (K: B fusion) or by point mutations of the BRAF gene itself.

The test developed by Garcia for the current study used fluorescent in situ hybridization (FISH) to visualize BRAF and its fusion partner KIAA1549 inside cells, allowing researchers to see when these genes were fused together and when they were apart.

An abnormal gene created by the fusion of ETV6 and the RUNX1 gene is one of the most common alterations in childhood ALL and is found in the leukemic cells of 20 to 25 percent of pediatric ALL.

In 2008, Dr. Côté's team explained the role of the DOCK1 and DOCK5 genes in the development of muscle tissue by showing that these two genes were critical regulators of the fusion process in mice.

Scientists have discovered a new «mastermind fusion gene» may be associated with a rare cancer - causing tumor — pheochromocytomas («pheo») and paragangliomas, according to a study published Feb. 13 in Cancer Cell, by researchers at the Uniformed Services University (USU) and the National Cancer Institutes» The Cancer Genome Atlas.

Dr. Iavarone and his colleagues suspected that glioblastomas might be addicted to proteins produced by gene fusions.

The result is that a fusion gene is created by juxtaposing the ABL1 gene on chromosome 9 (region q34) to a part of the BCR (breakpoint cluster region) gene on chromosome 22 (region q11).

These drugs are now being tested in patients with recurrent glioblastoma that contains the gene fusion by one of the paper's co-authors, Marc Sanson, MD, of Pitié Salpêtrière Hospital in Paris.

In a 2012 study published in Science, the CUMC team found that some cases of glioblastoma, the most common and aggressive form of primary brain cancer, are caused by the fusion of two genes, FGFR3 and TACC3.

Synovial sarcoma is a rare soft tissue sarcoma characterized by a t (X; 18) translocation, which results in a SYT - SSX gene fusion.

By engineering an artificial protein that targets the product of such potentially cancer - causing gene fusions, Hur hopes to trigger immune defense mechanisms that kill rogue cells harboring the fusions.

By combining pieces of different genes, fusion genes can lead to production of abnormal proteins that disrupt cell function.

Also, genes that code for receptor tyrosine kinases, a family of receptors on the surface of cells, may rearrange to form multiple distinct gene fusion partners, as evidenced in an article by Kulkarni, et al, on a translational study involving a patient who developed a BRAF fusion following treatment with a BRAF inhibitor1.

Research conducted by Jian - Hua Luo, M.D., Ph.D. of the Pittsburgh School of Medicine is the first time gene editing has been used to specifically target cancer fusion genes, which are hybrid genes discovered in a wide array of solid tumors1.

There are numerous, diverse mechanisms that allow a low frequency of gene movement between species, such as accidental fusion of cells between different species, or the injection of DNA by bacteria into plant cells.

In conjunction with these strains, several cre transgenic strains have been created where BAC engineering was used to insert an intron containing cre or creERT2 cassettes, followed by a polyadenylation sequence to terminate transcription of the fusion transcript immediately after the recombinase gene, into the BAC vector at the initiating ATG codon in the first coding exon of the gene.

Although dCas9 can tether different effectors, several dCas9 fusions (e.g., dCas9 - VP64 activator and dCas9 - KRAB repressor) can not be co-introduced with sgRNAs to regulate two set of genes differently since both fusions will bind to both set of genes directed by both sets of sgRNAs (Fig 1).

Blue jeans, which have been worn from miners, frontiersmen, blues men, rock and roll musicians, and members of contemporary hip - hop culture, have been claimed by the artist as homonym (genes) and metaphor, symbolizing a fusion of American culture and African ancestry.