Sentences with phrase «by tumour cells»

For cancer, he hopes to adopt a similar approach in which the transplanted nodes will contain T cells trained to hunt down the antigens produced by tumour cells and kill them off.

However, if it is known which unique antigen is expressed by a tumour cell type, it should be possible to clone a T - cell receptor that has the capacity to bind to that antigen.

Not exact matches

When placed at the site of a cancerous tumour in a rodent and «activated» by a scope with a light source, the compounds eradicated up to 100 % of cancer cells.

They conclude that the sperm made by these cells contained the disease - linked mutations and that the mutations may be driving the growth of the tumours (Nature Genetics, DOI: 10.1038 / ng.470).

These results were facilitated by the permanent cultivation of circulating tumour cells of patients with advanced SCLC in Vienna.

A «Trojan horse» treatment for an aggressive form of brain cancer, which involves using tiny nanoparticles of gold to kill tumour cells, has been successfully tested by scientists.

When chlorotoxin is tagged with a fluorescent dye, it will illuminate a tumour — a trick that makes the surgeon's job easier by helping to pinpoint cancerous growth and ensure that all the cancerous cells are removed and healthy tissue spared.

Rodríguez - Perales, Torres and Ramírez have shown that by transferring the RGEN components into primary human cells, regions of the exchanged chromosomes in some tumours can be marked, thus generating cuts in those chromosomes.

Within that sting lies a peptide called chlorotoxin, which has an unusual property — it sticks strongly to tumour cells while ignoring surrounding healthy tissue, by binding to a cancer - specific protein called matrix metalloproteinase - 2.

«Pancreatic cancer is extremely hard to treat by chemotherapy, so this finding is important because vitamin A targets the non-cancerous tissue and makes the existing chemotherapy more effective, killing the cancer cells and shrinking tumours.

They concluded that the sperm made by these cells contained the disease - containing mutations and that the mutations may be driving the growth of the tumours.

This is important as one of the reasons tumour cells are so pernicious is that they are able to hide from the body's immune system, by hijacking macrophages.

Batimastat does not work this way: instead, it is designed to keep cancers in check by preventing malignant cells breaking away and forming secondary tumours elsewhere in the body.

Infected individuals however, are constantly exposed to granulin - like proteins secreted by flukes, which subsequently cause host cells to proliferate uncontrollably, leading to tumour growth.

In research funded by Sparks charity, Great Ormond Street Hospital Children's Charity and Cancer Research UK, researchers at the University of Cambridge have developed a test for blood and cerebrospinal fluid samples that looks for a specific panel of four pieces of short genetic code known as microRNAs, which are found in greater quantities in malignant germ cell tumours.

The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumour) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body).

Using an approach developed at Maisonneuve - Rosemont, consisting of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41 %, a record level using this strategy.

Treatment is difficult because pancreatic tumours are protected by an armour of connective tissue, blood vessels and immune cells, known collectively as the stroma.

«Brain metastases are a secondary brain tumour, which means they are caused by cancer cells that escape from primary tumours like lung, breast or melanoma, and travel to the brain,» said Mohini Singh, the study's primary author and a PhD candidate in biochemistry at the Michael G. DeGroote School of Medicine at McMaster.

If these could be targeted to tumours — by attaching them to antibodies that recognise cancer cells, for instance — it would then be possible to destroy the malignant cells» DNA using lower doses of radiation or drugs.

Pembrolizumab works by binding to PD - 1 and blocking the interaction between PD - 1 and its ligands, PD - L1 and PD - L2, thereby activating T lymphocyte cells which may affect both tumour cells and healthy cells.

The CNIO researchers show that cell defects caused by the inhibition of Cdh1 are independent of the presence of the p53 molecule, which is mutated in different types of tumours.

The study, funded by the charity Brain Tumour Research and conducted by researchers at their UK Centre of Excellence at the University of Portsmouth, examined the factors present on the surface of NSCLC cells.

The TGF beta - 1 was produced by the stromal fibroblasts which surrounded the tumour cells.

A team working at the Institute of Cancer Research and the Royal Marsden Hospital in London, in collaboration with scientists at the National Cancer Institute in Bethesda, Maryland, has found that tamoxifen also works by encouraging the cells surrounding a tumour to produce a «growth factor».

First, the researchers inhibited the tumour cell mitochondria, by restricting the cancer cells only to glucose as a fuel source; then, they took away their glucose, effectively starving the cancer cells to death.

Cancer tumours manipulate a natural cell process to promote their survival suggesting that controlling this mechanism could stop progress of the disease, according to new research led by the University of Oxford.

Cancer stem cells, which fuel the growth of fatal tumours, can be knocked out by a one - two combination of antibiotics and Vitamin C in a new experimental strategy, published by researchers at the University of Salford, UK.

The immune response triggered by eczema could help prevent tumour formation by shedding potentially cancerous cells from the skin.

The team conducted investigations by grafting low - metastatic (LM) and high - metastatic (HM) melanoma tumour cells under the skin of mice.

The team plans to test the approach in a clinical trial in which chemotherapy drug selection for each person will be guided by testing balls of their tumour cells in the lab.

The decrease in metastasis caused by melanoma cells was especially dramatic and confirmed that NK cells lacking STAT3 are extremely efficient killers of tumour cells.

«This is because the stress led to poor function against the cancer by T - cells, which are very important in the immune system's control and surveillance of tumours and are a major target in many immunotherapy treatments.»

The research, led by scientists at The Institute of Cancer Research, London, is the largest study to date of the genetics of testicular germ cell tumours — the most common cancer in young men.

Preliminary experiments in cultured tumour cells confirm that the genomic instability present in these cells is partly caused by histone 1 deficiency.

Such genes might include those for various cytokines — substances produced by cells of the immune system — such as tumour necrosis factor, interleukins and interferons.

By understanding the survival factors that keep cancer cells alive we aim to develop new and effective drugs that can activate natural cell death or inhibit impaired survival mechanisms in tumour cells.

Tumours naturally suppress the immune response by secreting chemical messages that quiet T - cells.

Adenoma (benign tumour) formation - driven by mutational activation of the Wnt signalling pathway in intestinal stem cells

We have identified a number of key transcription factors that are deregulated during this process, and we are using this information to investigate mechanisms by which differentiation can be reprogrammed in tumour cells.

We target tumours by exploring how the proteins found on the cancer cell surface can be utilised to inhibit growth or kill tumours.

T - cells (red, yellow, and blue) attack a tumour in a mouse model of breast cancer following treatment with radiation and a PD - L1 immune checkpoint inhibitor, as seen by transparent tumour tomography.

Metastasis is the process by which cancer cells spread from one organ to another, forming secondary tumours.

Although these processes are affected by many different cell types within the tumour stroma, macrophages and other myeloid - derived cells are among the most important players.

If brain tumours are driven by neural stem cells with faulty developmental pathways, these transcription factors could potentially be good drug targets.

Research Paper Cancer Stem Cells are Regulated by STAT3 Signalling in Wilms Tumour Yanmei Liu, Xuexiang Gao, Shuo Wang, Xuemin Yuan, Yunqing pang, Jian Chen, Jing Wang J. Cancer 2018; 9 (8): 1486 - 1499.

The DNA from cancer cells is mutated and this mutated DNA can get into the blood stream (circulating tumour DNA, ctDNA) and be detected by sequencing the DNA in blood.

«I originally trained as a developmental biologist, then, during my postdoc in stem cell biology, I became interested in research showing that the growth of brain tumours might be driven by cells similar to neural stem cells.

By blocking of an enzyme that affects the cellular microenvironment it is possible to stop brain tumour cells from growing.

Navin, N. E. and Kendall, J. T. and Troge, J. E. and Andrews, P. and Rodgers, L. and McIndoo, J. and Cook, K. and Stepansky, A. and Levy, D. and Esposito, D. and Muthuswamy, L. and Krasnitz, A. and McCombie, W. R. and Hicks, J. B. and Wigler, M. H. (2011) Tumour evolution inferred by single - cell sequencing.