During the development of blood cells it is activated
by tyrosine phosphorylation and can switch certain genes on or off.
Not exact matches
Specifically, they are interested in those genes that are involved in
tyrosine phosphorylation — the attachment of a phosphate group (a phosphorous surrounded
by oxygen atoms) to distinct sites in protein chains where there is a
tyrosine residue.
The SDF - 1 / CXCR4 interaction stimulates
tyrosine phosphorylation of CXCR4, followed
by the activation of multiple G protein - dependent signaling pathways, which may be different among cell types.
Unlike IFNα - activated ISGF3 complex in which
tyrosine - phosphorylated STAT proteins are required, IRF - 9 could successfully interact with either wt STAT2 or mutant STAT2 - Y690F in the absence of IFNα, although the interaction between IRF - 9 and wt STAT2 could be obviously enhanced
by IFNα via
tyrosine phosphorylation of STAT2 (Fig. 2A).
The idea that both STAT2 and IRF - 9 were basic components necessary for RIG - G expression was also supported
by the fact that ATRA could not only induce the total amounts of STAT2 and IRF - 9 proteins but also increase the
tyrosine phosphorylation level of STAT2 in NB4 cells (Fig. 1A).
Here, we have shown for the first time that the unphosphorylated STAT2 could play an important role in RIG - G gene expression
by interacting with IRF - 9, further reinforcing the idea that STAT proteins could function as transcription factors in the absence of
tyrosine phosphorylation.
Requirement of
tyrosine phosphorylation for rapid activation of a DNA binding factor
by IL - 4.
Toxoplasma Rhoptry Protein 16 (ROP16) Subverts Host Function
by Direct
Tyrosine Phosphorylation of STAT6
Zinc is involved in insulin signaling
by inhibiting the enzyme protein
tyrosine phosphatase to increase
phosphorylation of the insulin receptor.
METHODS: We treated 3T3 - L1 adipocytes with 2.5 mmol / l R (+) alpha - lipoic acid for 2 to 60 min, followed
by assays of: 2 - deoxyglucose uptake; glucose transporter 1 and 4 (GLUT1 and GLUT4) subcellular localization;
tyrosine phosphorylation of the insulin receptor or of the insulin receptor substrate - 1 in cell lysates; association of phosphatidylinositol 3 - kinase activity with immunoprecipitates of proteins containing phosphotyrosine or of insulin receptor substrate - 1 using a in vitro kinase assay; association of the p85 subunit of phosphatidylinositol 3 - kinase with phosphotyrosine proteins or with insulin receptor substrate - 1; and in vitro activity of immunoprecipitated Akt1.