Sentences with phrase «by years of trial»

Not exact matches

Shares of pioneering CRISPR gene - editing firm Editas fell 7 % in early Tuesday trading after the company announced that it would delay an initial FDA filing for clinical trials of one of its lead drugs, LCA10, to the middle of next year (Editas had originally planned to file by the end of 2017).

The high - powered jetpack was 40 years in the making, the culmination of millions of dollars spent and decades of trial and error by Mayman and his business partner, Nelson Tyler.

And then when I watch the trials and tribulations of a business like L.L. Bean, whose good - faith commitment and lifetime guarantees to customers have been shamelessly abused for years by flea market phonies, eBay a-holes and other crafty resale store shoppers, I remember that things become clichés, not because they're pithy phrases, but because they're sadly too true.

In a decision released by the Baltimore Circuit Court, Judge Martin P. Welch wrote that the 35 - year - old was being granted a new trial because his initial council failed to properly cross-examine an expert from the state about the reliability of cell tower data that seemed to place him at the scene of the crime.

Regardless, the study has begun well ahead of the first planned American CRISPR trials, which won regulatory clearance earlier this year (and are being funded by tech billionaire Sean Parker) but are unlikely to begin until 2017 at the University of Pennsylvania.

The company did a sort of trial run earlier this year, by giving its blessing to a quasi-affiliate called Maiden Lane (named after the street in San Francisco where AngelList is based), which raised $ 25 million to support select syndicate deals with up to $ 100,000 each.

By leveraging the collective will and sociability of the student demographic — while remaining aligned with universities by collecting data and encouraging department collaboration — the jointly reformed Koofers.com gained enough momentum to grow from a one - campus beta trial in 2006 to a 400 - campus platform in 2009 — and a soon - to - be 1,000 - campus platform this yeaBy leveraging the collective will and sociability of the student demographic — while remaining aligned with universities by collecting data and encouraging department collaboration — the jointly reformed Koofers.com gained enough momentum to grow from a one - campus beta trial in 2006 to a 400 - campus platform in 2009 — and a soon - to - be 1,000 - campus platform this yeaby collecting data and encouraging department collaboration — the jointly reformed Koofers.com gained enough momentum to grow from a one - campus beta trial in 2006 to a 400 - campus platform in 2009 — and a soon - to - be 1,000 - campus platform this year.

In recent years, Bettencourt became a household name in France as the central figure in an infamous trial in which judges examined whether the billionaire was taken advantage of by those close to her.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

A new book on the Canadian workplace — Work on Trial: Canadian Labour Law Struggles, edited by Judy Fudge and Eric Tucker — provides an engaging and accessible account of various labour battles in the courts over the past 85 years involving human rights, employment fairness and union recognition.

After releasing a documentary on Kalief Browder, who spent three years awaiting trial on Rikers Island and committed suicide two years after he was finally released, the two are now prepping a series of projects about Trayvon Martin — the 17 - year - old black teenager who was stalked and fatally shot by George Zimmerman in Florida in 2012.

CNN: Saudi Islamist preacher on trial in daughter's slaying Outrage is mounting in Saudi Arabia about the case of a 5 - year - old girl who died after allegedly being beaten and tortured by her father, who activists say is an Islamist preacher.

The readers, which were tested during a trial involving 40 churches last year, are capable of supporting 500 transactions without recharging, although the vast bulk of regular donating is expected to continue by standing order.

State District Judge Steve Thomas of Hardin County implemented a temporary injunction Thursday in favor of the Kountze High School cheerleaders, and by setting a trial date of June 24, 2013, Thomas effectively allows the cheerleaders to keep displaying Bible - quoting signs at Kountze athletic events through the end of this current school year.

Years later, Galileo's trial pivoted on the question of whether he had also been ordered not to «teach» Copernicanism «in any way,» but by then Bellarmino was long dead and the signed affidavit he had given Galileo was ignored by the Inquisition.

The result of years of careful research, trial - and - error, and a little creative reverse - engineering, Top Secret Recipes ® Step - by - Step hacks: • KFC ® Original Recipe ® Fried Chicken and Cole Slaw • Cinnabon ® Classic Cinnamon Roll • IKEA ® Swedish Meatballs • Outback Steakhouse ® Alice Springs Chicken ® • Pinkberry ® Original Frozen Yogurt • Raising Cane's ® Chicken Fingers and Sauce • Arby's ® Curly Fries • Lofthouse ® Frosted Cookies • Wendy's ® Chili • Panera Bread ® Fuji Apple Chicken Salad • Starbucks ® Cake Pops • Cafe Rio ® Sweet Pork Barbacoa • McDonald's ® McRib ® Sandwich • The Melting Pot ® Cheddar Cheese Fondue • P.F. Chang's ® Chicken Lettuce Wraps • The Cheesecake Factory ® Stuffed Mushrooms • Ben & Jerry's ® Chocolate Chip Cookie Dough Ice Cream • Chick - fil - A ® Chicken Sandwich • Chili's ® Baby Back Ribs • Chipotle Mexican Grill ® Adobo - Marinated Grilled Chicken & Steak • Cracker Barrel ® Hash Brown Casserole • Mrs. Fields ® Chocolate Chip Cookies • Ruth's Chris Steakhouse ® Sweet Potato Casserole

By Mary Edmonds, Rodale Institute Seasonal Research Technician Rodale Institute is currently in the second year of a series of field trials investigating organic weed management using cover crops.

A trial of «traffic - light» food labels was recommended by a respected former Labor health minister, Neal Blewett, officially appointed to head an inquiry into the matter after years of government prevarication.

First asked by the world's leading manufacturer of high - quality cocoa and chocolate products, Barry Callebaut, to consider how their environmental responsibility and waste recovery processes could be enhanced by reviewing their packaging, experts at the 168 year old, family - run mill began a series of trials that soon lead them to their breakthrough.

In the Olympic crew trials, four schoolboys (high school) came within two feet of catching a Navy crew manned by Annapolis graduates seven years older.

In the next four years I expect to read about Max leading George Washington University to the kind of prominence enjoyed by its D.C. neighbor, Georgetown, and, with luck, see his name where Patrick Ewing's was this year, in a story on the 1988 Olympic basketball trials.

Developed by a Boston - based company, SmartSports, the SmartKage has been in a trial stage over the past year «'' which led to its installation at the Concord baseball school, one of just 100 test sites chosen across the country.

Arsenal tried to bring in Sobhy on a trial basis earlier this year, which was rejected, and he is now the subject of a bid by Stoke City.

Over the years he attended countless unsuccessful trials at a number of France's big names, before finally being picked up by Boulogne, a side plying their trade in Ligue 3 of French Football.

«The trial of Charlie Alliston last year highlighted that there is a gap in the law concerning death caused by careless or dangerous cycling, and we recognise that the outdated law used to convict Alliston was not fit for purpose in the 21st century.

Morrison is rated as one of the most exciting prospects in English football, but his rise to the top has been halted by a string of disciplinary issues, varying from skipping training and being fined, to almost going to prison for intimating a witness in an assault trial last year.

Recognized by clients and lawyers alike for his superior level of trial work, Cohen has been listed for the past three years as a Southern California «Super Lawyer» as chosen by his peers and through the independent research of Law & Politics magazine.

The program of prenatal and infancy home visiting by nurses described above produced treatment - control differences in 15 - year - olds» arrests and reductions in arrests and convictions among 19 - year - old females.32, 33 In a subsequent trial with a large sample of urban African - Americans the program produced treatment impacts on 12 - year - olds» use of substances and internalizing disorders.34

A trial court in Rensselaer County has thrown out a union challenge to a pair of programs started by Cuomo — the Empire and Excelsior Service fellowships — that recruits young professionals and those just getting out of school, to work at high level jobs in state government for two year periods.

The two workers were evidently granted a new trial by a different judge later in 2007, and in November of that year wound up accepting a plea deal that allowed them to serve probation without actually admitting to any wrongdoing.

Bharara was fired by President Donald Trump last year, but his wish is about to come true: The high - profile trial of Percoco and three co-defendants on charges that Percoco was bribed to exercise influence on behalf of a power company and Syracuse developers starts Monday in a federal court in Manhattan.

Zemsky, a Buffalo businessman who is $ 1 a year by the state for his work, told reporters outside the hearing that he does not expect the ongoing corruption trials to affect the work of his agency.

At a City Council hearing on criminal discovery practices in February chaired by Queens councilman Rory Lancman, Sergio de la Pava, a supervising attorney for New York County Defender Services who has been representing indigent defendants in Manhattan for over 20 years, described a typical experience in the borough's courtrooms: After waiting six months or a year for trial, he said, «The DA comes in with a cart and drops about six inches of material on your desk.

Zemsky, a Buffalo businessman who is paid one dollar a year by the state for his work, told reporters outside the hearing that he does not expect the ongoing corruption trials to affect the work of his agency.

The trial of the man charged with detonating a bomb in Chelsea last year began in Federal District Court in Manhattan with video replays of the blast, emotional testimony from people wounded by shrapnel and an outburst by the defendant that led to his ejection from the courtroom.

After 6 weeks of studying the over one year court proceedings on the ongoing trial involving four suspects; Osarfo Anthony, Ekow Micah, Sarah Kwablah, and Chris Handler, accused of allegedly conspiring to extort money from Asamoah Gyan, the new Attorney General headed by Madam Gloria Akuffo, is set to appear in court for trial to continue.

Cole is the first Democrat to publicly announce a bid against Collins, whose fifth year in Congress has been marked by controversy over his investment in an Australian biotech company that critics said could have benefited from his work on a bill aimed at speeding clinical trials of new drugs.

Sheldon Silver, who for years was one of the most powerful politicians in the state, was «blinded by greed,» Assistant U.S. Attorney Damian Williams said in opening statements at Silver's bribery trial in federal court in Manhattan.

His wife of 53 years, Camille, has stood by his side, but it remains unclear if she will attend the trial in person.

The report highlights the money spent by CPV on lobbying and other public relations efforts as the trial of Joe Percoco approached last year.

A federal judge rejected attempts by four of the Buffalo Billion defendants to move next year's corruption trial to Buffalo, keeping the high - profile case in lower Manhattan instead.

Just this past year, legislative changes show New Yorkers can make a difference: by raising the age of criminal responsibility, enacting bail reform, ensuring access to a speedy trial, improving witness identification procedures and requiring video - taped police interrogation for serious offenses.

Nowhere is that effort more lacking than in the realm of reform, a decades - long need in New York exacerbated by the embarrassing fall from power of two of the three men in the room with Cuomo only a few years ago and now magnified by the conviction of a one - time gubernatorial buddy in a blistering corruption trial.

The papers, which respond to arguments raised by the attorney of the former aide, Joe Percoco, push back against claims federal prosecutors did not provide defense lawyers enough time to respond before the trial begins early next year.

This has been preceded by a flurry of media headlines, subjecting him to an open - air political trial and a trial in the court of NPP public opinion supported with earlier pressure from some leading Members of New Patriotic Party (NPP) on Government, to commence prosecution of former NDC Government appointees including Dr. Stephen Kwabena Opuni for alleged acts of corruption for over a year now.»

Meanwhile the Court of Appeal has fixed November 13, 2017 for hearing of the Appeal filed by Dasuki in which he prayed the court to set aside the subpoena issued on him by Justice Abang on the ground that he had been in the custody of DSS for over two years and may not be able to give accurate evidence in the trial of Metuh.

ALBANY — Longtime Albany lawmakers and observers were shocked Monday by the conviction of former Assembly Speaker Sheldon Silver, one of Albany's most powerful leaders for 20 years, on all counts in his corruption trial.

For years, according to testimony during former Senate Majority Leader Joseph L. Bruno's 2009 trial, members of the state Senate's Republican conference were instructed to submit their annual financial disclosure forms by hand rather than through the mail in order to avoid potential federal mail fraud charges.

In addition to complicating Cuomo's campaign efforts — and the potential for a presidential run in 2020 that some political watchers see in his future — the trials could provide plenty of distractions as he and the state Legislature tackle a multi-billion budget deficit by the April 1 start of the new fiscal year.

Trial lawyers gave the max to state Assembly Democrats» fund - raising arm and the central campaign committee of the party controlling the Senate in each of the last seven years, a copy of the report obtained by The Post shows.