Then they use polymerase chain reaction (PCR) to amplify a 300 - nucleotide Alu insertion into an intron of H -
cadherin gene.
«We wanted to see if field - resistant pink bollworm from India harbored these same changes in
the cadherin gene,» Fabrick said.
He said that by collaborating with Indian scientists, «we discovered that the same
cadherin gene is associated with the resistance in India, but the mutations are different and much more numerous than the ones we found in lab - selected pink bollworm from Arizona.»
Not exact matches
The study builds on more than a decade of research from Cummings School of Veterinary Medicine and the University of Massachusetts Medical School that in 2010 initially found the neural
cadherin (CDH2)
gene on canine chromosome 7 appeared to coincide with an increased risk of OCD.
In the lab strains, the scientists had identified mutations in a
gene encoding a protein called
cadherin.
Four
genes, all with synaptic function, have the most case - only variation: neuronal
cadherin (CDH2), catenin alpha2 (CTNNA2), ataxin - 1 (ATXN1), and plasma glutamate carboxypeptidase (PGCP).
CNRQ values were calculated by classic delta - delta - Ct method and normalized to the multiple housekeeping
genes,
cadherin - associated protein, beta 1 (CTNNB1) and GAPDH using the qBasePlus 1.3 analysis software.
To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven
genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the
genes coding for synaptosomal - associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in
cadherin 13 (CDH13).
In their work on compulsive blanket and flank sucking in Dobermanns, the authors identified a single locus with genome - wide significance within the
gene Cadherin 2 (cdh2), a widely expressed
gene involved in pre - and post-synaptic adhesion.