Not exact matches
have shown
caffeine to increase the metabolic rate
between 3 - 11 %, with larger
doses (within reason) having a more pronounced effect.
Generally, a
dose between 250 - 500 mg (check
caffeine amounts here) could produce some of the above mild to moderate symptoms, especially in those with no tolerance of high
caffeine sensitivity.
Symptoms usually peak
between 20 - 51 hours after the last
caffeine dose, last from 2 - 9 days and may include [16,25,51,132]:
Association
between coffee or
caffeine consumption and fecundity and fertility: a systematic review and
dose - response meta - analysis.
This conclusion is based on prospective cohort studies showing a
dose - dependent positive association
between caffeine intakes during pregnancy and the risk of adverse birth weight - related outcomes (i.e. foetal growth retardation, small for gestational age) 26.
One paper reported weak positive associations
between maternal
caffeine consumption and spina bifida (neural tube defects), but without a
dose - effect relationship and with a negative association for tea.
An inverse
dose - response relationship was observed
between caffeine consumption and depression risk in our multivariate model (P for trend =.02, Figure).
We observed an inverse
dose - response relationship
between caffeine or caffeinated coffee consumption and depression risk, but we were unable to address the effects of very high consumption because only 0.52 % of our participants drank 6 or more cups per day of caffeinated coffee.