«We have been able to produce a precise omics - level molecular atlas of the aortic valve and the molecular network of
calcific aortic valve disease,» said first author Florian Schlotter, MD, a research fellow in the Center for Interdisciplinary Cardiovascular Sciences at BWH.
It's been over two years since Smash Bros. creator, Masahiro Sakurai, first revealed that he was suffering from
calcific tendinitis in his right shoulder and while from his tone, it appears his condition has improved, he obviously has not yet fully recovered.
Sakurai is currently suffering
from calcific tendinitis in his right shoulder.
Their findings have tremendous implications
for calcific aortic valve disease (CAVD), the third most common heart condition, and related forms of heart disease.
In addition to building molecular networks for the fibrotic and
calcific stages of CAVD, the researchers also determined that CAVD has a prominent inflammatory fingerprint.
Dr. Deepak Srivastava, Ms. Christina Theodoris, Dr. Benoit Bruneau, and Dr. Katherine Pollard identified master regulators that
control calcific aortic valve disease.
Marion Hofmann - Bowman, MD, PhD, associate professor in the Section of Cardiology at the University of Chicago, will speak factors that
modify calcific aortic valve disease.
The creator of Super Smash Bros. suffers from
calcific tendonitis in his right shoulder, and it shows: Sakurai often holds his arms as he talks, and he says he can't use a regular mouse anymore.
Two years ago, Sakurai revealed that he had
calcific tendinitis in his right shoulder, and it appears he is still having problems.
This deeply integrated team worked seamlessly to unravel the basis
for calcific aortic valve disease.
Calcific aortic valve disease (CAVD)-- a disease that leaves the aortic valve stiff and calcified, preventing blood flow from the heart into the aorta — affects one quarter of the U.S. population aged 65 and over.
«A molecular atlas of
calcific aortic valve disease: Study builds molecular networks of calcific aortic valve disease to identify key molecules and therapeutic targets for a disease that affects one in four older Americans.»
Calcific aortic valve disease (CAVD) is the third leading cause of heart disease, affecting nearly 1.5 million people and resulting in 100,000 heart valve replacement surgeries in the U.S. alone.
Calcific aortic valve disease (CAVD) causes calcium to accumulate in heart valves and vessels until they harden like bone.
Sakurai has repeatedly flirted with the idea of retirement or moving on from the Smash Bros. series, and those thoughts have gotten stronger over the years as
his calcific tendinitis has made working long hours quite painful.