Sentences with phrase «calcineurin as»
Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.
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For example, CRAC channels in T cells have been clinically validated as important drug targets through human mutations and the use of calcineurin inhibitors that act downstream from CRAC channels.
Studies from a group at the University of Glasgow, which are published in the same issue of the journal, show the importance of calcineurin through different stages of the malaria life - cycle, implicating the protein as a potential target for blocking malaria transmission.
They show that it is a substrate for calcineurin, the phosphatase target of the immunosuppressive drugs cyclosporin A and FK506, and that it exists in activated cells as a complex with the transcription factor AP - 1 (Fos - Jun).
We also characterized the function of a family of endogenous inhibitors of calcineurin, originally termed MCIP but subsequently renamed as RCAN proteins.