Sentences with phrase «calcineurin in»
Angiotensin II signalling and calcineurin in cardiac fibroblasts: differential effects of calcineurin inhibitors FK506 and cyclosporine A. Therapeutic Advances in Cardiovascular Disease, 6 (1), 5 — 14.
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For example, CRAC channels in T cells have been clinically validated as important drug targets through human mutations and the use of calcineurin inhibitors that act downstream from CRAC channels.
In the cohort of patients who received transplants from mismatched unrelated donors, all 43 patients received four doses of abatacept with a calcineurin inhibitor and methotrexate.
Researchers at Boston College working in collaboration with the Harvard Chan group showed that calcineurin is also important for cellular attachment by a related parasite that causes toxoplasmosis.
Studies from a group at the University of Glasgow, which are published in the same issue of the journal, show the importance of calcineurin through different stages of the malaria life - cycle, implicating the protein as a potential target for blocking malaria transmission.
«In addition to a possible drug target, calcineurin underlies a very basic aspect of parasite biology.»
They show that it is a substrate for calcineurin, the phosphatase target of the immunosuppressive drugs cyclosporin A and FK506, and that it exists in activated cells as a complex with the transcription factor AP - 1 (Fos - Jun).
We are particularly interested in the calcineurin - NFAT pathway and mTOR pathway in immune signaling.
Schreiber's work on the FK506 - binding protein FKBP12 in 1988, along with his colleague Gerald Crabtree's discovery of the NFAT proteins, led to the elucidation of the calcium - calcineurin - NFAT signaling pathway.
It prevents a certain specific group of lymphocytes (immune system cells) the helper T - lymphocytes, from transmitting chemical messages (calcineurin / interleukins) that result in histamine release from your dog's skin mast cells.
A second problem with Atopica is that the calcineurin messenger compounds that it blocks are also found in your pet's kidneys.