Sentences with phrase «calcitriol in»

While the long - term goal of the team is to understand the function of calcitriol in inflammatory diseases, identifying the kidney - specific enhancer region of the genome is already yielding insights into the mechanisms involved in bone disorders.

Not exact matches

Calcitriol production is carried out by the enzyme CYP27B1, but the genomic regions that the team deleted in the experimental mice are far away from the gene encoding this enzyme.

In these non-kidney sites, calcitriol seems to serve an altogether different purpose: it appears to play no role in regulation of minerals, and its production is induced by inflammation rather than by the hormones that control calcitriol synthesis in the kidneyIn these non-kidney sites, calcitriol seems to serve an altogether different purpose: it appears to play no role in regulation of minerals, and its production is induced by inflammation rather than by the hormones that control calcitriol synthesis in the kidneyin regulation of minerals, and its production is induced by inflammation rather than by the hormones that control calcitriol synthesis in the kidneyin the kidneys.

Inactive vitamin D obtained from the diet or produced in the skin is converted to its active form, calcitriol, in the kidneys.

Calcitriol can also be produced in other parts of the body, including skin cells and immune cells.

Calcitriol induces G0 / G1 arrest, modulates p27Kipl and p21Waf1 / Cipl, the cyclin dependent kinase (cdk) inhibitors implicated in G1 arrest.

Calcitriol mediates its biological effects by binding to the vitamin D receptor (VDR), which is principally located in the nuclei of target cells.

Calcitriol, the hormonally active form of vitamin D, accumulates in the adrenals, and this stimulates the production of the gene for tyrosine hydroxylase, which is involved in serotonin production.

In fact scientists debate that calcitriol is the most powerful hormone in the human bodIn fact scientists debate that calcitriol is the most powerful hormone in the human bodin the human body.

In rats, experimental calcium deficiency in the presence of adequate vitamin D caused a more than four-fold elevation of calcitriol and a more than 60 percent drop in 25 (OH) D from just under 40 ng / mL to about 15 ng / mL (4)(click to enlargeIn rats, experimental calcium deficiency in the presence of adequate vitamin D caused a more than four-fold elevation of calcitriol and a more than 60 percent drop in 25 (OH) D from just under 40 ng / mL to about 15 ng / mL (4)(click to enlargein the presence of adequate vitamin D caused a more than four-fold elevation of calcitriol and a more than 60 percent drop in 25 (OH) D from just under 40 ng / mL to about 15 ng / mL (4)(click to enlargein 25 (OH) D from just under 40 ng / mL to about 15 ng / mL (4)(click to enlarge):

It's all calcidiol, ready for storage in fat tissue or dispersal to the kidneys for conversion into calcitriol, also known as 1,25 (OH) D. Calcitriol is the active hormonal form whose primary role is to regulate blood calcicalcitriol, also known as 1,25 (OH) D. Calcitriol is the active hormonal form whose primary role is to regulate blood calciCalcitriol is the active hormonal form whose primary role is to regulate blood calcium levels.

If there's enough calcidiol left in the tank after the calcium duties, it gets sent to other tissues in the body to be converted into more calcitriol to fulfill even more roles.

Bypassing the kidney's control over calcitriol levels which involves the emergency measure of depositing excess calcium in the soft tissues is very serious situation to have occur over long periods of time.

In this way, calcitriol, which is the active form of vitamin D, has the ability to activate over 1,000 genes in the body (8In this way, calcitriol, which is the active form of vitamin D, has the ability to activate over 1,000 genes in the body (8in the body (8).

Secondly, calcitriol is also the hormone responsible for regulating circulating calcium levels in the blood.

Although the action is not immediate, PTH also stimulates conversion of vitamin D to its active form (1,25 - dihydroxyvitamin D; calcitriol) in the kidneys.

In the kidneys, PTH stimulates the conversion of vitamin D into its active form (1,25 - dihydroxyvitamin D; calcitriol), which rapidly decreases urinary excretion of calcium but increases urinary excretion of phosphorus.

The fat - soluble vitamin D is unique in two ways: 1) It is produced mostly via sun exposure, and 2) the active form of vitamin D, calcitriol, actually functions as a hormone.

Vitamin D derivatives like calcitriol (Rocaltrol, Calcijex) and calcipotriene (Dovonex), used to treat a wide range of human conditions including psoriasis, thyroid problems, and osteoporosis, can cause fatal blood calcium level spikes in your dog or cat.

In addition, healthy kidneys are required to process vitamin D into calcitriol to preserve calcium for bones and for normal calcium balance in the boIn addition, healthy kidneys are required to process vitamin D into calcitriol to preserve calcium for bones and for normal calcium balance in the boin the body

Naturally occurring hypercalcemia (too much calcium in the blood stream) can lead to pancreatitis and it is likely that over supplementation with calcium or calcitriol could also lead to pancreatitis.

«These types of cancer locally convert calcidiol to calcitriol, a vitamin D metabolite that has significant anti-cancer activity in preclinical models, and could prove to be an important adjunct therapy.»