Sentences with phrase «calcium channels in»

Excitable cells, such as skeletal muscle and nerve cells, contain voltage - dependent calcium channels in their cell membranes that allow for rapid changes in calcium concentrations.

Now this may just be me, but it seems to be the case with a lot of people as well and it may have something to do with not getting adequate deep sleep and the disruption of brain waves caused by the calcium channels in the brain not operating properly.

(2005) Pressure - Induced Production of Inflammatory Cytokines and Activation of NF B Is Modulated by Calcium Channels in Retinal Glia (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 3579).

Inhibitory effect of somatostatin - 14 on L - type voltage-gated calcium channels in cultured cone photoreceptors requires intracellular calcium.

The role of calcium release activated calcium channels in osteoclast differentiation.

The researchers studied calcium channels in neurons, which allow for the transport of calcium ions from one nerve cell to another, helping the cells transmit itch signals from the skin to other cells in the spinal cord.

«It appears there is cross-talk between pathways called calcium channels in sensory nerve cells that process the itch signal.»

The latest research implicates both glutamate transmission and calcium channels in schizophrenia development.

His laboratory already has shown that by inhibiting calcium channels in T - cells, they were able to prevent T - cell activation in animal models of autoimmune diseases like multiple sclerosis and colitis.

They found that the number of functional docking sites matches the number of clusters of voltage-gated calcium channels in the presynaptic terminal.

«Our study highlights the important role of STIM1 and calcium channels in shutting down the immune response to chronic infection and in preventing injurious inflammation,» Feske says.

Absence seizures are believed to be elicited by T - type calcium channels in the thalamic reticular nucleus of the brain that regulate influxes of calcium.

The study is meaningful in respect to the fact that it calls into question the role of the T - type calcium channel in the reticular thalamus, and is expected to provide an important theoretical foundation for understanding its role in the mechanism of absence seizures, as well as developing effective treatment methods for absence epilepsy.

Not exact matches

In many nerve cells, magnesium serves as Nature's own calcium channel blocker, preventing calcium from rushing into the nerve cell and activating the nerve.

The researchers found that puffing activated a mechanosensitive channel protein called TRPV4, which is enriched in the membrane of neuronal axons and allows calcium ions to enter the cell.

«It is not yet known whether there's actually an increase or decrease in the flow of calcium ions through the channel,» Olesen says.

The pathogenic IgG modified neither kinetics of calcium channel activation nor elementary channel activity, suggesting that a reduction in the number of functional calcium channels underlies the IgG - induced effect.

If one component was missing in this triplet consisting of auxin transporter, receptor or calcium channel, there was no cellular response.

Since calcium channels are only found in heart and brain tissue, the researchers sought a drug approved to block these pathways.

These drugs, now in preliminary testing, seem to target the brain systems responsible for addiction One such medication, isradipine (Dynacirc), is a calcium - channel blocker most often prescribed for hypertension.

This leads to a large increase in the amount of a special calcium ion channel in the nerve cells and overall, this significantly boosts the risk of epileptic seizures.

In fact, the study of additional auxin mutants suggested that both a special receptor complex and a calcium channel were involved.

The researchers also identified the specific neuron responsible for detecting high pH. They did this by showing that when a specific sensing neuron, called the ASH neuron, was destroyed by laser microsurgery, the worms no longer avoided high pH. Going another step further, the researchers also identified some of the proteins involved in the response to high alkalinity, which make up a calcium channel.

Toshihiro Sassa and Takashi Murayama, the first and second authors of the paper, respectively, say, «we would like to identify the other genes involved in downstream signaling from this calcium channel to understand how the signal leads to aversion to high pH.» Sensing alkaline environments is only the first step; the worm must then quickly react to the stimulus by moving away.

«In this current study, we've shown that by opening the TRPV1 channel to allow calcium ions to enter the cell, we can turn on a gene.

The pepper - derived compound creates a sensation of heat in patients who apply the cream by binding to TRPV1s, heat - activated calcium channels that are located on the surface of pain - and heat - sensing neurons.

Kingsley speculates that in its normal form, the ank protein is a pyrophosphate channel that allows pyrophosphate levels to remain high in cartilage throughout life to prevent calcium phosphate crystal formation in the joint cleft.

Calcium ions then travel through the channel, switching on a synthetic piece of DNA the scientists developed to turn on the production of a downstream gene, which in this study was the insulin gene.

In this study, the team, which included Dr. Meerim Nurbaeva and Miriam Eckstein in Dr. Lacruz's lab, for the first time used freshly dissected enamel cells (ameloblasts) from rodent teeth to modulate physiological processes in order to understand the contribution of CRAC channels in enamel calcium signalinIn this study, the team, which included Dr. Meerim Nurbaeva and Miriam Eckstein in Dr. Lacruz's lab, for the first time used freshly dissected enamel cells (ameloblasts) from rodent teeth to modulate physiological processes in order to understand the contribution of CRAC channels in enamel calcium signalinin Dr. Lacruz's lab, for the first time used freshly dissected enamel cells (ameloblasts) from rodent teeth to modulate physiological processes in order to understand the contribution of CRAC channels in enamel calcium signalinin order to understand the contribution of CRAC channels in enamel calcium signalinin enamel calcium signaling.

The team found that the main calcium influx pathway involved in the mineralization of enamel [called the CRAC (Ca2 + release - activated Ca2 +) channel — the main type of SOCE (Store - operated Ca2 + entry) channel — is critical for controlling calcium uptake, which is necessary for the development of tooth enamel.

A team of researchers led by Rodrigo Lacruz, MSc, PhD, assistant professor in the Department of Basic Science and Craniofacial Biology at NYU College of Dentistry, has published a paper in Scientific Reports (5:15803) titled «Dental enamel cells express functional SOCE channels,» which reports the results of a study showing for the first time the mechanism of calcium transport essential in the formation of dental enamel.

The binding of positively charged calcium ions in its vicinity opens the channel and allows negatively charged chloride ions to permeate across the membrane.

Enamel defects can be caused by genetic mutations affecting either the STIM1 calcium sensor in the endoplasm reticulum or in the ORAI channel in the cell membrane.

NPTX2 causes multiple GluR4 proteins to unite and form a channel into the cell, which allows calcium to flow in.

The mutation resulted in a lower single channel conductance for calcium and a strongly increased conductance for sodium and potassium, indicating that glutamic acid - 95 is a crucial constituent of the ion selectivity filter.

Coauthor Dr. Stefan Feske, of the New York University School of Medicine Department of Pathology, in 2006 discovered ORAI channels, which open and close to allow calcium into cells.

A study co-led by Ryuichi Shigemoto, Professor at the Institute of Science and Technology Austria (IST Austria), with Alain Marty, Professor at Université Paris Descartes, uncovers that a single docking site may use a single cluster of calcium channels and that both the number of docking sites and the number of calcium clusters change in parallel with brain age.

Specifically, they determined that the immune systems in genetically altered mice lacking the critically important calcium channel component STIM1 failed to control TB, leading to severe lung inflammation and premature death.

In the patients» spheroids, interneurons migrated inefficiently but, by adding drugs that blocked the dysfunctional calcium channel, the researchers could reverse the problem.

Specifically, the bipolar neurons expressed more genes for membrane receptors and ion channels than non-bipolar cells, particularly those receptors and channels involved in the sending and receiving of calcium signals between cells.

«Like in all immune modulatory therapies,» Feske adds, «the benefits of incomplete calcium channel inhibition need to be balanced against the dysregulation of the immune response that results when these channels are blocked completely,»

Researchers at Johns Hopkins have spotted a strong family trait in two distant relatives: The channels that permit entry of sodium and calcium ions into cells turn out to share similar means for regulating ion intake, they say.

The implications of a common control element in sodium and calcium channels are vast, Yue says, including unified understanding of conditions that spring from defects in the calcium control of these channels.

«We thought that the conflicting results for sodium channels might be related to difficulties in existing methods to control the calcium concentrations that might affect these channels,» Ben - Johny says.

«When we exposed a near - infrared laser beam to these animal models injected with both the nanoparticle and the genetically engineered immune cells, this caused calcium channels on the dendritic cells to open and we saw a corresponding increase in the number of T - cells that were activated,» said Han.

The researchers discovered T - type channels in the pond snail, Lymnaea stagnalis, can shift from using calcium ions to using sodium ions to generate the electrical signal.

They found that, as with calcium channels, increasing calcium concentrations caused calmodulin to bind within the resemblance element of sodium channels and prevent their opening, just as in calcium channels.

The researchers discovered T - type channels in the pond snail, Lymnaea stagnalis, can shift from using calcium ions to using sodium ions to generate the electrical signal because of an outer shield of amino acids called a turret situated above the channel's entrance.

By screening already approved drugs, the team led by Postdoctoral Researcher Guillaume Jacquemet and Academy Professor Johanna Ivaska has discovered that calcium channel blockers can efficiently stop cancer cell invasion in vitro.

A cryo — electron microscopy structure provides a framework for understanding function and disease mechanisms in a family of calcium channels.