Sentences with phrase «calcium signals in»

This work provides evidence that a GRAS protein transduces calcium signals in plants and provides a possible regulator of Nod - factor - inducible gene expression.

In our study, pentobarbital inhibited 5 - HT evoked calcium signals in geniculate ganglion neurons and, at anesthetic levels in mice, significantly inhibits 5 - HT3 function in vivo.

The experiments revealed that the creation of a wound generates a complex series of calcium signals in the surrounding tissue:

Therefore, even after genetic elimination of the 5 - HT3 receptor, no other serotonin receptors were capable of generating a calcium signal in the ganglion cells.

Interaction between P2X3 and ERα / ERβ in ATP - mediated calcium signaling in mice sensory neurons.

Thrane AS, Thrane VR, Zeppenfeld D, Lou N, Xu Q, Nagelhus EA, Nedergaard M General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex Proc Natl Acad Sci U S A (in press)

Not exact matches

The burning in your belly for a double helping of chocolate double latte ice cream may be signaling a need for more calcium or fat.

Their new insights are described in a paper titled «Multiple mechanisms drive calcium signal dynamics around laser induced epithelial wounds» published Oct. 3 by the Biophysical Journal.

Calcium - based signaling is used in many cellular and neuronal processes to initiate rapid responses to extracellular signals.

«Our studies suggest that the local auxin signals can be communicated over long distances using calcium waves in order to generate an auxin signal also in target cells located far away,» Hedrich says.

Toshihiro Sassa and Takashi Murayama, the first and second authors of the paper, respectively, say, «we would like to identify the other genes involved in downstream signaling from this calcium channel to understand how the signal leads to aversion to high pH.» Sensing alkaline environments is only the first step; the worm must then quickly react to the stimulus by moving away.

When exposed to capsaicin, these receptors open to allow in sodium and calcium ions, causing the receptors to transmit that hot signal to the brain.

Latest research from the National Centre for Biological Sciences (NCBS, Bangalore), now shows that maintaining Calcium balance in cells is also needed for another purpose — it may be regulating the levels of an important signalling molecule called dopamine in the brain.

They find that two different stimulus signals can produce two different patterns of calcium waves (that is, two different responses) in an astrocyte.

In this study, the team, which included Dr. Meerim Nurbaeva and Miriam Eckstein in Dr. Lacruz's lab, for the first time used freshly dissected enamel cells (ameloblasts) from rodent teeth to modulate physiological processes in order to understand the contribution of CRAC channels in enamel calcium signalinIn this study, the team, which included Dr. Meerim Nurbaeva and Miriam Eckstein in Dr. Lacruz's lab, for the first time used freshly dissected enamel cells (ameloblasts) from rodent teeth to modulate physiological processes in order to understand the contribution of CRAC channels in enamel calcium signalinin Dr. Lacruz's lab, for the first time used freshly dissected enamel cells (ameloblasts) from rodent teeth to modulate physiological processes in order to understand the contribution of CRAC channels in enamel calcium signalinin order to understand the contribution of CRAC channels in enamel calcium signalinin enamel calcium signaling.

First, looking at a study of 185 cases of childhood epilepsy, Wittkowski's team found that mutations in genes that control axonal guidance and calcium signaling — both of which are important early in the developing brain when neurons are forming the appropriate connections — led to increased chances of having the disorder.

Their work implicated the Ras pathway — a calcium - dependent signaling network that spurs neuronal growth — as playing a key role in autism.

«Elevated calcium triggers multiple signaling pathways that promote cell doubling, survival and changes in the cell that promote cancer invasion and metastasis,» says Dr. Copland.

In general, lithium alters the way calcium signals are sent and received — and the new cell lines will make it possible to study this effect specifically in bipolar disorder - specific cellIn general, lithium alters the way calcium signals are sent and received — and the new cell lines will make it possible to study this effect specifically in bipolar disorder - specific cellin bipolar disorder - specific cells.

However, Feske and his colleagues found that calcium signals also are required for the development of iTreg cells and that their numbers are strongly reduced in the lungs of the infected STIM1 - deficient mice.

The close temporal association of the [Ca2 +] i transient with the onset of anaphase suggests that calcium may have a signaling role in this event.

«What we saw in mice lacking STIM1 — whose T - cells can not generate calcium signals — is that the number of mycobacteria in their lungs was dramatically increased, resulting in excessive inflammation,» says Stefan Feske, MD, an associate professor of pathology at NYU Langone and the study's senior author.

Specifically, the bipolar neurons expressed more genes for membrane receptors and ion channels than non-bipolar cells, particularly those receptors and channels involved in the sending and receiving of calcium signals between cells.

Neural signals are transmitted within neurons by changing calcium concentrations, so the researchers used this technique to measure the amount of calcium contained within the Purkinje cells in real time.

How calcium signals are elicited in different and separate areas of plants is not yet fully understood.

«Calcium signaling regulates many important cellular functions, like muscle contraction, neural communication, gene transcription and tissue growth,» said Fenfang Li, a postdoctoral research fellow in Zhong's laboratory and lead author of the study.

Of general importance for systemic calcium signaling is the wounding of the vascular system of the leaf, which is also responsible for the internal transport of water and nutrients in the plant.

Calcium ions are important messengers for the processing of wound signals in plant cells.

Enikolopov says: «If the calcium signal coincides in time with a wave or a puff of nitric oxide — which might be produced even by a neighbouring cell — then this weak calcium signal effectively becomes a strong signal, in terms of its consequences.»

The IZN researchers assume that similar switches based on nuclear calcium signals may have applications in other areas — presumably whenever organisms need to adapt to new conditions over the long term.

The researchers discovered T - type channels in the pond snail, Lymnaea stagnalis, can shift from using calcium ions to using sodium ions to generate the electrical signal.

Moreover, the scientists showed that calcium signaling can be studied directly in intact plants in different physiological and ecological contexts, which helps to better understand its role as a secondary messenger in plants.

The researchers discovered T - type channels in the pond snail, Lymnaea stagnalis, can shift from using calcium ions to using sodium ions to generate the electrical signal because of an outer shield of amino acids called a turret situated above the channel's entrance.

«We succeeded in visualizing the dynamic signal processing of intracellular calcium as a secondary messenger which is elicited by insect feeding and transmitted systemically to unattacked areas of the plant,» Axel Mithöfer, the leader of the project group «Physiology of Plant Defense» in the Department of Bioorganic Chemistry, summarizes the results of the study.

In order to visualize this signal, the scientists performed experiments with transgenic Arabidopsis plants which were genetically modified to express a protein in the cytosol, the liquid inside the cells, which breaks down and releases light energy after it has bound calcium ionIn order to visualize this signal, the scientists performed experiments with transgenic Arabidopsis plants which were genetically modified to express a protein in the cytosol, the liquid inside the cells, which breaks down and releases light energy after it has bound calcium ionin the cytosol, the liquid inside the cells, which breaks down and releases light energy after it has bound calcium ions.

Surprisingly, the application of larval oral secretions inhibited the transduction of calcium signals to neighboring leaves in the experiment.

«It appears there is cross-talk between pathways called calcium channels in sensory nerve cells that process the itch signal.»

The researchers studied calcium channels in neurons, which allow for the transport of calcium ions from one nerve cell to another, helping the cells transmit itch signals from the skin to other cells in the spinal cord.

Kummer's group is working in an area that has intrigued biochemists for decades — the role of calcium in hormone - induced cell signalling.

Uncontrolled calcium signaling and ROS in the mitochondria is behind a number of common diseases, such as stroke or heart attack, and is thought to play a role in diseases of aging such as neurodegenerative disease.

The researchers also identified the molecular mechanisms — particularly the role of signals from calcium ions — involved in this effect.

Since calcium ions spike when neurons fire a signal, Yuste and Dupre were able to relate behaviour to activity in glowing circuits of neurons.

It is not clear how this calcium signal might relate to mouse embryos, in which rotating cilia help set up left and right sides (ScienceNOW, 3 July, 2002).

«Bacterial and host cell proteins interact to regulate Chlamydia's «exit strategy»: New research suggests major role for calcium ion signaling in release of Chlamydia from infected cells.»

Additional experiments showed that genetic disruption of MrcA, depletion of ITPR3, and depletion of STIM1 all significantly inhibited extrusion in infected cells, as did chemical disruption of calcium ion signaling.

These findings suggest an important role for calcium ion signaling in regulating extrusion and could help improve understanding of how the bacterium leaves an infected cell and spreads within the body of an infected person of animal.

As soon as the calcium level exceeds a particular threshold value over a longer period of time, a signal cascade is triggered that initiates production of the body's tanning pigment melanin in the genetically modified cells.

In support of the idea that Themis is involved in TCR signaling, this protein was phosphorylated quickly after TCR stimulation and was needed for optimal TCR - driven calcium mobilization and activation of the kinase ErIn support of the idea that Themis is involved in TCR signaling, this protein was phosphorylated quickly after TCR stimulation and was needed for optimal TCR - driven calcium mobilization and activation of the kinase Erin TCR signaling, this protein was phosphorylated quickly after TCR stimulation and was needed for optimal TCR - driven calcium mobilization and activation of the kinase Erk.

Many functional categories of genes were represented in these analyses, including calcium signaling, cytokines, and growth factor pathways.

Role of initial protein phosphorylation events and localized release - activated calcium influx in B cell antigen receptor signaling.