The scientists also found that endothelial cells themselves give the signal for their own death: To do this, the vascular wall cells have a receptor molecule
called Death Receptor 6 (DR6) on their surface.
Many receptors in this family, including CD95 are
called Death Receptors because of their ability to induce apoptosis2.
Not exact matches
Kite Pharma, one of the companies chasing a new generation of cancer drugs
called chimeric antigen
receptor T - cell (CAR - T) therapies, announced a patient
death in a clinical trial of its experimental KTE - C19.
For some years now, a new class of drugs
called antibody - drug conjugates (ADCs) have been used, which work in two ways: they consist of an antibody that binds selectively to the tumor cell
receptor and interrupts the signal to propagate; they also act as a transport vehicle for a chemical substance that enters the cancer cells with the antibody and triggers their
death.
To devise a potential new therapy, the investigators engineered a population of neural stem cells to express a potent version of a gene
called TRAIL, which codes for a molecule that activates cell -
death - inducing
receptors found only on the surface of cancer cells.