Many people have a hard time with this process, either due to a genetic variation
called MTHFR or impairments in the gut.
It turned up a gene mutation
called MTHFR that can cause blood clots that keep nutrients from getting to the placenta.
Not exact matches
The
MTHFR gene provides instructions for making an enzyme
called methylenetetrahydrofolate reductase.
MTHFR is an enzyme that converts inactive folate into the active form
called 5 - methyltetrahydrofolate (5 - MTHF).
And you know, what people understand is that you - you may not have any copies of
MTHFR, that you can have what I
call a functional polymorphism where those pathways are not working because of too much oxidative stress, or environmental chemicals, or nutrient deficiencies.
B12 might also be high due to an active
MTHFR mutation along with an active COMT mutation, so patients tend to avoid the synthetic supplemental version of B12
called cyanocobalamin and instead favor the methylcobalamin (methylB12) or adenosylcobalamin (also the active form, but used by your mitochondria), but they will need adequate folate supplementation.