When investigating clusters of shigellosis — the infection caused by shigella — in Massachusetts, California and Pennsylvania, the CDC discovered that 90 % of the cases were resistant to an antibiotic
called ciprofloxacin (Cipro), which is the drug of choice when treating shigellosis.
In 2008, Jin and coworkers published in Nature Biotechnology their discovery that certain antibiotics
called fluoroquinolones (
ciprofloxacin is one) can make the RNA interference process work more efficiently — in general.