Sentences with phrase «called gene silencing»

Tycko studies a phenomenon called gene silencing, in which one of a person's two copies of a gene is shut off.

Not exact matches

The gene - silencing strategy, in the form of RNA interference, has also showed promise against an uncommon neurodegenerative disease called hereditary ATTR amyloidosis, as my colleague Sy Mukherjee wrote about in Fortune's year - end Investor's Guide.

Some of the genes in sperm and egg cells have chemicals called methyl molecules that attach to them, a process called methylation; these molecules can either activate or silence a gene when the sperm and egg DNA unite in an embryo.

The bits, called short interfering RNA, then associate with other enzymes to form a large complex that can silence certain genes and render the virus harmless.

The technique, called «RNA interference,» silences expression of a gene — it doesn't genetically knock it out as CRISPR does.

A European team of scientists has discovered how the cells produce tiny pieces of RNA — called piRNA — that identify and silence «jumping genes» or transposons: genes that are able to change their position within the genome and therefore alter or disrupt the genetic code.

One of Beaudet's graduate students — Linyan Meng — was writing her dissertation on Angelman syndrome and was wrestling with this problem when a member of her dissertation committee, Dr. Thomas Cooper, professor of pathology & immunology at Baylor, said he was working with a Carlsbad, Calif. - based company called Isis Pharmaceuticals that had anti-sense oligonucleotides that could turn off the antisense transcript that silenced the paternal copy of the gene.

He or she also has a paternal copy of the gene, but it is silenced by a long ribbon of RNA called the UBE3A anti-sense transcript.

Most research on epigenetics has focused on the way everyday experiences alter patterns of gene activity in DNA during life through a chemical process of gene tagging called methylation, which usually silences genes.

That could be very helpful right now as we are testing a new generation of so - called «gene silencing» drugs that we hope will put the brakes on the condition.

The body already has a way to silence an extra chromosome: a gene called XIST, which turns off the second X chromosome in females.

Some of these molecules are a complex of proteins called the Polycomb Repressive Complex 2 (PRC2) that is involved in «silencing» genes so that they are not «read» by the cellular machinery that decodes genetic information, effectively keeping the genetic information in the «off» state.

The genetic signal, also called a microRNA, silences certain genes in the DNA.

Foltz's team has also used the mouse atlas to help home in on two genes, known as BEX1 and BEX2, which seem to be silenced in a form of brain cancer called glioma.

Much of the previous research on epigenetics has focused on the fact that everyday experiences alter patterns of gene activity in DNA during life through a chemical process of gene tagging called methylation, which usually silences genes.

The researchers at Bonn University and their colleagues from the Federal Institute of Drugs and Medical Devices (BfArM) and from the University of Regensburg worked with so - called transgenic and knockout mice in whom the gene for micro-RNA 155 was either increased or silenced.

Double - stranded RNA can silence the expression of a gene with a corresponding sequence, a process called RNA interference (RNAi).

These traits are diametrically opposite to the traits that show up in fragile X, a condition in which a mutation silences the gene called FMR1, or fragile X mental retardation 1.

RNAi silences genes using small pieces of RNA called small interfering RNAs (siRNAs).

It is caused when a gene called FMR1 is silenced, which typically inhibits learning.

To test their theory, the researchers investigated what would happen to fetal mouse brains if they interfered with Trnp1 expression using synthetic sequences of genetic material that silenced the gene, a technique called RNA interference.

In recent years researchers have eyed a gene called Lin28a, which is active early in life but silenced in most mature tissues.

We perform the transient silencing of several genes in parallel by RNA interference in order to identify those able to modify two types of DM1 biomarkers expressed by one DM1 - hES cell line progeny: the pathological intranuclear ribonucleoaggregates called foci and the insulin receptor splicing defect.

What these groups are attempting basically is «gene silencing», with a twist - it's aimed directly at the DNA, rather than targeting a «message molecule» called RNA.

The third PDR approach and the one that we intend using not only for MSV resistance but also for other viruses such as MRDV, is based on something called RNA - mediated gene silencing.

In other work, the lab is exploring the mechanisms of heterochromatin formation and gene silencing through the study of a protein complex called RNA - induced initiation of transcriptional gene silencing (RITS).

ALS can be caused by a mutation in a protein called SOD1, and the antisense drug effectively silences the gene that codes for this mutant protein — found in the cells of patients with inherited forms of ALS.

By probing the three dimensional structure of this protein complex, called RNA - Induced Initiation of Transcriptional gene Silencing (RITS), scientists from Cold Spring Harbor Laboratory (CSHL) and their collaborators at St. Jude's Research Hospital have discovered new details of how its various parts or «domains» contribute to heterochromatin assembly and gene sSilencing (RITS), scientists from Cold Spring Harbor Laboratory (CSHL) and their collaborators at St. Jude's Research Hospital have discovered new details of how its various parts or «domains» contribute to heterochromatin assembly and gene silencingsilencing.

Double - abdomen formation occurred when this gene, called panish, was silenced in early Chironomus embryos.

It fingered a gene called NR1H3, finding that a rare mutation silences other genes involved in regulating inflammation or other aspects of immunity.

«Now that we have the gene, we can actually use that gene sequence to temporarily silence the gene and make rye and other chromosomes pair with wheat and transfer genes by a natural method into wheat without calling it GMO,» Gill said.

MicroRNA - 143 silences genes linked to an enzyme called AKT and so stops insulin activating AKT.

The potential of a gene - silencing technique called RNA interference has long enticed biotechnology researchers.

The results could help us understand how patterning and reorganization of DNA - containing material called chromatin in a cell's nucleus relate to a cell's specialized function as specific genes are activated or silenced.

By injecting molecules called short interfering RNAs directly into tissue known as the trabecular meshwork, researchers have been able to silence the action of disease - relevant genes.

Now, a major deal between Isis Pharmaceuticals and drug giant Roche promises to support the development of one kind of gene silencing drug, called ASOs, taking them through to clinical trials in patients as quickly and efficiently as possible.

One possible implication of this work is for so - called «gene - silencing» therapies for Huntington's disease, which aim to reduce production of the huntingtin protein, by sticking to its RNA message molecules and telling cells to get rid of them.

One of the best ways to love up your DNA is to get adequate methylation — a biochemical process in the body that occurs when a compound called a methyl group binds to a gene and changes the way it expresses itself — methylation is involved in DNA silencing.

Silencing Viral Genes Beeologics» solution, Remebee, utilizes a mechanism called RNA interference (RNAi, also known as gene silencing) a mechanism that inhibits or hinders gene exSilencing Viral Genes Beeologics» solution, Remebee, utilizes a mechanism called RNA interference (RNAi, also known as gene silencing) a mechanism that inhibits or hinders gene exsilencing) a mechanism that inhibits or hinders gene expression.