After months of passing the hat among countries and private companies, the U.S. National Institutes of Health (NIH) announced today that it has garnered the $ 100 million the 3 - year effort to construct a so -
called haplotype map is likely to cost.
Large blocks of DNA,
called haplotypes, are thought to come in only a handful of variants.
Efforts include the National Institutes of Health Diabetes Genome Anatomy Project and another NIH - sponsored venture, the International HapMap Project, which is creating a map of regions in the human genome
called haplotypes, where the underlying DNA influences common diseases like diabetes.
The process of figuring out which of these genetic differences lie on each chromosome is
called haplotyping, and it's an important step toward identifying which version of a gene may cause disease.
Not exact matches
So
called «matching
haplotypes» could prevent the dangerous effect.
Researchers proved its utility by successfully mapping the multi-drug resistance genes in a strain
called Salmonella Typhi
haplotype H58 — which has recently emerged globally.
Results: BCFtools / csq is a fast program for
haplotype - aware consequence
calling which can take into account known phase.
No genes that produce abnormal proteins were found, but instead the elevated risk appears to come from groups of tightly - linked DNA sequences
called «
haplotypes» that regulate the expression of protein - coding genes.