These findings
call into question the safety of the recent substitution of DiNP for DEHP in soft PVC, particularly since a shorter male AGD has been shown to be related to male genital birth defects in children (such as hypospadias and undescended testis) and impaired reproductive function in adult males (such as decreased fertility, impaired semen quality and lower
serum testosterone levels) and the fact that
human levels of DiNP are rapidly increasing globally, says Carl - Gustaf Bornehag, professor in Public Health Sciences at Karlstad University and responsible for the current study.
Based on the observation that obese mice, rats, and
humans all had elevated
serum concentrations of a protein
called GDF15 compared to lean controls, Yumei Xiong and colleagues set out to develop therapies derived from the molecule.