«We showed that there are markers on these stomach tumour cells that indicate they would be responsive to a type of immunotherapy
called immune checkpoint inhibitors, in particular anti-PDL1 immunotherapy, which is already used with great success in the treatment of melanoma and certain other cancers.
The novel drug combination allows the rapidly emerging cancer therapies
called immune checkpoint inhibitors to be incorporated into a transplant patient's cancer treatment regimen.
A new class of drugs
called immune checkpoint inhibitors block molecules on T cells that shut down immune response, freeing the immune system to attack tumors.
Not exact matches
One recent tally found more than 1100 studies combining a popular new class
called checkpoint inhibitor drugs, which unleash suppressed
immune cells, with other treatments.
They are designed to get around one of the ways that cancer protects itself from the
immune system: tumors can activate the body's natural protective response from autoimmunity,
called a
checkpoint, and thereby thwart cytotoxic T cells.
Researchers led by Van Allen and Choueiri sought an explanation for why some patients with a form of metastatic kidney cancer
called clear cell renal cell cancer (ccRCC) gain clinical benefit — sometimes durable — from treatment with
immune checkpoint inhibitors that block the PD - 1
checkpoint, while other patients don't.
BMS's Opdivo is the second FDA - approved
checkpoint inhibitor targeted at an
immune protein
called PD - 1.
In recent years, though, discoveries have led to a new class of drugs
called checkpoint inhibitors, which have mobilized the
immune system to see and go after cancer.
Under normal conditions, so -
called checkpoint inhibitor molecules rein in the
immune system to ensure that it does not attack the body's own cells, tissues and organs.
It is also the first in an emerging class of therapies
called «
checkpoint blockade,» which enhance the
immune system's ability to attack cancer by interfering with immunological
checkpoints that slow or stop
immune cell activation and proliferation in the presence of tumors or chronic viral infection.