The biggest development has been the rediscovery of a promising, yet fraught, drug
called ketamine.
Not exact matches
Janssen has developed a specific form of
ketamine,
called esketamine, that it is testing in five large clinical trials.
Gould and his colleagues used a battery of behavioural tests in mice to show that one of
ketamine's breakdown products — a compound
called (2R, 6 R)- hydroxynorketamine — is responsible for much of the drug's antidepressant effects.
The participants were randomly assigned to receive either a «dummy» placebo nasal spray, or
ketamine in a nasal spray form
called esketamine.