The investigators also discovered that a potent suppressor of autophagy (
called mTOR) was hyperactivated in the
kidneys of obese mice, and treatment with an mTOR inhibitor ameliorated autophagy
insufficiency.
Other health issues in Dobermans include autoimmune hemolytic anemia, immunoglobulin deficiencies,
kidney disease, pancreatic
insufficiency, liver shunt, and a severe liver disease
called chronic active hepatitis.