Sentences with phrase «called leukemia»

When the bone marrow or peripheral blood is affected, it is called leukemia.

The tumors appear as sold growths which begin in the lymph nodes or bone marrow or as individual cells freely circulating in the blood, in which case they are called leukemia.

This leads to the formation of so - called leukemia stem cells.

One reason for this, explains Hai - Hui (Howard) Xue, MD, PhD, UI professor of microbiology and immunology, is that there are two kinds of tumor cells — bulk leukemia cells that can be killed by TKI drugs, and a subset of cells called leukemia stem cells, which are resistant to TKIs and to chemotherapy.

Physicians and families may call the Leukemia Program at 1 -800-CANCER9.

Not exact matches

«I am calling upon him to take those donations out of his $ 27 million campaign coffer and donate them to a worthy institution that treats children with life - threatening allergies who can't afford EpiPens or with pediatric cancers like leukemia and Hodgkin's who are suffering because of generic drug shortages that he causes,» Long said in a statement.

Using a relatively new technology called CRISPR / Cas9, they managed to accurately cut out specific DNA sequences from leukemia cells.

In turn, these modifications are caused by two specific proteins of the so - called chromatin regulator group, on which leukemia cells are dependent.

Changes in the genetic code (mutations) that reduce TET2 function are found in 10 percent of patients with acute myeloid leukemia (AML), 30 percent of those with a form of pre-leukemia called myelodysplastic syndrome, and in nearly 50 percent of patients with chronic myelomonocytic leukemia.

It will not be easy, but Porter is hopeful that one day doctors specializing in other cancers will experience what he did when examining one of his leukemia patients not long after that phone call on the quad: He felt under the man's arm for his lymph nodes, which had been enlarged by the cancer for years.

These engineered cells, called CAR - T cells, were effective for some people against relapses of leukemia over the long term.

However, genetic mutations in a gene called mixed lineage leukemia, or MLL, lead to an aggressive subtype of B - ALL known as MLL - rearranged, which is the most common type of acute lymphoblastic leukemia in infants.

The most common cancer in children is called B - acute lymphoblastic leukemia, also known as B - ALL.

A gene therapy treatment called CAR - T immunotherapy has been approved for use in a rare type of leukemia.

The team has shown that the microenvironment that controls hematopoietic stem cells can be targeted for the treatment of a set of disorders called myeloproliferative neoplasias, the most prominent of which are chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), and atypical chronic myelogenous leukemia (CML).

With this new understanding of the enzyme, called Inositol trisphosphate 3 - kinase B (ItpkB), scientists are closer to improving therapies for diseases such as bone marrow failure syndrome, anemia, leukemia, lymphoma and immunodeficiencies.

In patient - derived animal models, they found that just three doses of the compound, called 17S - FD - 895, significantly reduced the ability of leukemia stem cells to self - renew.

A panel of outside experts convened by the FDA voted 10 - 0 Wednesday to recommend the approval of Novartis» CAR - T therapy, called CTL019, for the treatment of children and young adults with advanced leukemia.

The engineered cells contain an antibody - like protein known as a chimeric antigen receptor (CAR), which is designed to bind to a protein called CD19 found on the surface of B cells, including the cancerous B cells that characterize several types of leukemia.

The vaccine sets off an immune response using a piece of a protein, called PR1 peptide, found on the surface of leukemia cells.

Studies conducted in China and the United States demonstrated that arsenic — long considered a carcinogen — helps treat a blood cancer called acute promyelocytic leukemia.

One mutation, called NQO1 * 2, increases the risk of cancer or cancer relapse, especially for leukemia.

The researchers studied a class of anti-cancer drugs called BET inhibitors, which are considered promising new drugs for the treatment of blood cancers such as leukemias and lymphomas.

Dr Xu showed that for BET inhibitors to successfully kill lymphoma and myeloid leukemia cells the presence of a protein called BIM, which brings on apoptosis, was critical.

Leukemia stem cells promote an aggressive, therapy - resistant form of the disease called blast crisis.

Self - renewal of blast crisis chronic myeloid leukemia cells was reduced by approximately 40 percent when treated with the small molecule, called 8 - Aza, as compared to untreated cells.

They then tested the effect of a second drug molecule called misoprostol, which also interacts with EP4, and showed that misoprostol also has the ability to combine with TKI and significantly reduce the number of leukemia stem cells.

When investigators treated the leukemia cells with a JQ1 - and - phthalimide «conjugate» called dBET1, the BRD4 protein within the cells was degraded in less than an hour.

When Ralph Arlinghaus, a molecular biologist at the University of Texas MD Anderson Cancer Center in Houston, learned that growth factor — starved healthy cells release a protein called 24p3 that causes them to die, he wondered if leukemia cells also use the molecule to kill off their competition.

But following the onset of leukemia in some trials (ScienceNOW, 7 March 2005), scientists began to wonder whether IL2RG or another viral gene was inserting itself in the patients» DNA in a way that disrupted a class of genes called oncogenes, which can cause cancer if mutated.

Gerrit Jan Schuurhuis of the Free University Medical Center in Amsterdam and his colleagues recently identified the new marker, called C - type lectin - like molecule - 1 or CLL - 1, in 92 percent of people with a form of acute myeloid leukemia.

In 1972, she identified a genetic glitch in chronic myelogenous leukemia cells — a swap of genes she called chromosomal translocation — that resulted in the uncontrolled cell growth of cancer.

Acute myeloid leukemia (AML) is characterized by a rapidly - developing cancer in the myeloid line of blood cells, which is responsible for producing red blood cells, platelets and several types of white blood cells called granulocytes.

Patients with a rare type of leukemia called acute promyelocytic leukemia (APL) have better outcomes than most leukemias because they can be treated with a very...

Dr. June: Our initial pilot trial was for 10 patients, and was so - called «third line» therapy for patients who have progressive leukemia after having had at least two different kinds of FDA - approved therapy.

Children with certain variants of a gene called TMPT, for example, can't break down some of the drugs used for leukemia, which end up poisoning their bone marrow.

CAR T - cell treatment, on the other hand, is being widely tested in children and has shown impressive effectiveness against the most common childhood leukemia, called acute lymphoblastic leukemia.

All people have two copies of every gene, and earlier work by the researchers on identical twins with leukemia indicates that a second genetic alteration - involving the second copy of the TEL gene, one of the two so - called «alleles» — occurs post-natally to actually nudge blood cells into a leukemic state.

Researchers reveal genetic secrets of a high - risk pediatric leukemia called Ph - ALL, and find treatment potential in the drug ruxolitinib.

The changes included reductions in the use and dose of radiation therapy and chemotherapy drugs called anthracyclines for treatment of acute lymphoblastic leukemia (ALL), Hodgkin lymphoma and Wilms tumor, a cancer of the kidneys.

That case became even stronger with the discovery in 2008 of a mutated gene for a metabolic enzyme called IDH (isocitrate dehydrogenase) in some leukemias, brain cancers, and gall bladder and gastrointestinal cancers.

«Thanks to improvements in the understanding of AML biology, a multiplicity of so - called targeted therapies and therapies based on differential pathophysiology of leukemic stem cells compared with normal counterparts have emerged,» noted Richard M. Stone, MD, clinical director of the Adult Leukemia Program at Dana - Farber Cancer Institute in Boston, and colleagues, writing in a review for the ASCO 2017 Educational Book.

In fact, mutations in a human protein highly related to the yeast histone methyltransferase Set1, called MLL, are involved in leukemia.

Abnormalities in a gene called FLT3 (pronounced flit - 3) are common among patients with acute myeloid leukemia.

And doctors at the Great Ormond Street Hospital in London recently reported using a similar gene - editing technique called TALENs, which also recognizes and cuts precise DNA sequences, to engineer immune cells for a therapy that may have cured two infants of leukemia.

Previously, MDS was commonly referred to as a preleukemic condition (and it is still sometimes called pre-leukemia) because some people with MDS develop acute leukemia as a complication of the disease.

Previous reports have shown that in a genetic abnormality called Philadelphia chromosome, fusion of ABL and BCR genes cause leukemia.

A drug called dasatinib was found to be safe and effective for children with chronic myeloid leukemia, according to a clinical trial published in the Journal of Clinical Oncology.

Leukemia that starts in lymphoid cells — which make different types of white blood cells — is called lymphocytic or lymphoblastic lLeukemia that starts in lymphoid cells — which make different types of white blood cells — is called lymphocytic or lymphoblastic leukemialeukemia.

In patients with leukemia, immature cells called «blasts» overtake their healthy bone marrow.