Sentences with phrase «called mutant huntingtin»

In humans, Huntington's is an inherited disease caused by a gene encoding a toxic protein, called mutant huntingtin, which causes brain cells to die.

Not exact matches

It is caused by a single gene abnormality which leads to the production of a mutant form of a protein called huntingtin (mHtt).

The test, called a «single molecule counting assay», combines fluorescent antibodies with a laser detection chamber to count individual molecules of mutant huntingtin with a very low detection threshold.

In July, Elena Cattaneo and her colleagues at the University of Milan reported that mutant huntingtin affects another key neuron - survival protein called brain - derived neurotrophic factor (BDNF).

Next, Grima looked at cell death in cultured neurons with a healthy or a mutant form of Huntingtin, or with a mutant form of Huntingtin that was treated with small amounts of an experimental drug called KPT - 350, one that prevents a nuclear export protein, Exportin - 1, from shuttling proteins and RNA out of the nucleus.

Huntington's patients have a mutant form of a protein called huntingtin that contains between 36 and 120 repeats of the amino acid glutamine, where unaffected individuals have just a couple dozen repeats.

In this study, we employed a method called optical pulse - labeling, or OPL, which allowed us to see how the mutant huntingtin ravaged the brain over time — neuron by neuron.»