In some fields of engineering, they're
called nanoparticles.
So they developed a drug that inactivates the gene that makes FL2 and then put the drug in tiny gel capsules
called nanoparticles and applied the nanoparticles to wounds on mice.
Engineers are working on a way to combine tiny, tiny pieces of gold,
called nanoparticles, with an elastic polymer to create a stretchable, conductive material.
Not exact matches
As a proof of concept for this study, the researchers tested the plant virus - derived
nanoparticles with a nematicide
called crystal violet, which has been used to kill nematodes on skin but not in agriculture.
For this study, Yanik's team developed a new technology to inject RNA carried by
nanoparticles called lipidoids, previously designed by Daniel Anderson, an associate professor of chemical engineering, member of the Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science, and an author of the new paper.
The team produced the tiny
nanoparticles using a synthesis technique known as the solvothermal method, in which precursors are heated under pressure in a special vessel,
called an autoclave.
This interacted with proteins on the cell surface
called proteoglycans which led to the
nanoparticles being ingested by the cell.
The first,
called bio-bar-code assays, relies on
nanoparticles designed to attach themselves to specific disease - causing proteins; these will vastly improve a doctor's ability to detect diseases like cancer and Alzheimer's in their early stages and to identify pathogens like anthrax.
Back at the lab, the scientists turned the ginger into what they are
calling GDNPs, or ginger - derived
nanoparticles.
The
nanoparticles carry a drug compound that blocks a protein
called Myc that is active in many types of cancer, including multiple myeloma.
These
nanoparticles,
called magnetosomes, are usually arranged as a chain inside the bacteria.
The investigators utilized a targeting method
called RNA interference (RNAi) which, when delivered via these natural
nanoparticles or exosomes, zero in on mutant KRAS in pancreas cancer cells, impacting tumor burden and survival in multiple pancreas cancer models.
The
nanoparticles cluster into supraballs at room temperature in a mixture of water and an alcohol
called octanol, and are easy to extract as a powder.
The tetrapod - shaped zinc - oxide
nanoparticles,
called ZOTEN, have negatively charged surfaces that attract the HSV - 2 virus, which has positively charged proteins on its outer envelope.
The team coated flexible strands of silicon rubber with a mix of long chains of carbon atoms,
called carbon nanotubes, and tiny bunches of silver molecules,
called silver
nanoparticles.
The technology, developed by MIT professor and Howard Hughes Medical Institute investigator Sangeeta Bhatia, relies on
nanoparticles that interact with tumor proteins
called proteases, each of which can trigger release of hundreds of biomarkers that are then easily detectable in a patient's urine.
When combined with the compound,
called ganciclovir, these loaded
nanoparticles were 100 percent effective at killing glioma cells grown in laboratory dishes.
«We then evaluated the system in rats with glioma and found that by using a method
called intracranial convection - enhanced delivery, our
nanoparticles could penetrate completely throughout the tumor following a single injection,» says Jordan Green, Ph.D, associate professor of biomedical engineering and ophthalmology at Johns Hopkins.
Using
nanoparticles designed and screened for endothelial delivery of short strands of RNA
called siRNA, the researchers were able to target RNAi to endothelial cells, which form the linings of most organs.
Anderson and Langer have previously developed
nanoparticles, now in clinical development, that can deliver siRNA to liver cells
called hepatocytes by coating the nucleic acids in fatty materials
called lipidoids.
Acids naturally found in the organic matter of soil, collectively
called humic acid, can protect rice seedlings from the cell damage and stunted root growth caused by copper oxide
nanoparticles, researchers report April 13 in Environmental Toxicology and Chemistry.
The light - sensitive cells and
nanoparticles,
called opto - CRAC, were then delivered with the tumor antigen surrogate ovalbumin to mice with melanoma tumors in their lymph nodes to see if an immune response could be activated to target cancer cells.
The lipid membrane of these photoactivable multi-inhibitor nanoliposomes (PMILs) contains a FDA - approved photosensitizer
called BPD (benzoporphyrin derivative), and the
nanoparticles are loaded with a molecular therapy drug
called XL184 or cabozantinib.
«These novel luminescent
nanoparticles,
called upconversion
nanoparticles, have become promising candidates for a whole variety of ultra-high tech applications such as biological sensing, biomedical imaging and 3D volumetric displays,» says lead author Dr Tim Zhao, from the University of Adelaide's School of Physical Sciences and Institute for Photonics and Advanced Sensing (IPAS).
«Using the DNA barcoding technique, which we
call Joint Rapid DNA Analysis of
Nanoparticles (JORDAN), we are able to do the testing in just three animals.»
The nanosensor design presented in this study combines three - dimensional plasmonic
nanoparticles with singularities
called exceptional points — a combination that's being demonstrated for the first time.
To maximize this effect, the team created larger spheres,
called microparticles, filled with about a hundred
nanoparticles per microparticle, and held together by another type of biodegradable «glue.»
The ability to enhance
nanoparticle uptake is dependent on the level of expression of a molecule,
called NRP - 1, to allow the peptide to bind to the tumor blood vessels.
Daniel Getts, chief scientific officer of Cour Pharma in Chicago, Illinois, says he has written WHO to suggest the use of his company's Immune Modifying
Nanoparticles, designed to reduce tissue damage by binding immune cells
called monocytes.
They then attached an ending to the
nanoparticles, a process
called functionalisation.
These particles,
called micelles, are one type of a class of materials known as
nanoparticles.
To detect this sort of enzyme, the researchers designed
nanoparticles coated with small protein fragments
called peptides that can be cleaved by particular proteases
called MMPs.
For the future, Lin envisions more complex nanocrystals with multifunctional shells and additional shapes, including nanorods and so -
called «Janus»
nanoparticles that are composed of biphasic geometry of two dissimilar materials.
The method is
called «3D Structure Identification of
Nanoparticles by Graphene Liquid Cell EM (SINGLE)» and it exceeds previous techniques by combining three recently developed components.
Then, they etched the
nanoparticles off the film; the resulting interconnected pores —
called «mesopores» because of their size — cause the otherwise stiff material to behave somewhat like a sponge.
Instead of coating the
nanoparticles with polyethylene glycol, the researchers covered them with a bacterial protein
called streptavidin.
The scientists further coated the
nanoparticles with a fluorescent molecule
called DyLight549, which functions as a molecular thermometer, glowing with different intensities at different temperatures.
In their experiment, the team synthesized what they
call interfering
nanoparticles, or iNOPs, made from repetitively branched molecules of a small natural polymer
called poly - L - lysine.
A team of biophysicists from the State University of New York (S.U.N.Y.) at Buffalo used magnetic
nanoparticles to control heat - activated protein gates
called ion channels embedded in the membranes of nerve cells, allowing the researchers to stimulate a simple reflex in nematode worms at will.
Whereas in the nematode experiment the researchers targeted
nanoparticles to temperature - sensitive ion channels that naturally exist in the membranes of the worms» nerve cells, the scientists inserted the gene for a heat - activated ion channel
called TRPV1 into the human and rat cells.
In the diamond lattice inside each
nanoparticle, several individual spins are trapped inside of defects
called nitrogen vacancies.
The
nanoparticles assemble themselves from zinc and a drug
called oxaliplatin, which is widely used against advanced - stage metastatic colon cancer.
Monsanto is also the financial backer of a 15 - person company
called Preceres, a kind of skunk works it established just off the campus of MIT, where robotic mixers are busy stirring RNA together with coatings of specialized
nanoparticles.
«In our research, we use
nanoparticles - the liposomes we have created with TRAIL protein - and attach them to natural killer cells, to create what we
call «super natural killer cells» and then these completely eliminate lymph node metastases in mice,» said King.
The researchers applied the so -
called AF4 Method to detect
nanoparticles.
Scientists based at Imperial College London have tested a new type of
nanoparticle called metal organic frameworks (MOF)-- tiny metal cages less than...
Also, with some
nanoparticles much of the material ends up trapped in protective sacs
called endosomes inside the cell, and there can be potential toxic side effects.
Central to the new
nanoparticle tech is an enzyme
called caspase, which is activated when cells die.
The study focused on a class of
nanoparticles called quantum dots.
In this study, the
nanoparticles stay suspended in a liquid «ink,» creating a new nanomaterial
called a COF colloid.