The tested compound looks and acts like the chemical building blocks of DNA,
called nucleosides.
While the hospital advocates transitioning Charlie to end - of - life palliative care — officials have stated that «he has no quality of life and no real prospect of any quality of life» — his parents want him to undergo a highly experimental treatment in the United States
called nucleoside bypass therapy.
He's currently focused on reformulating drugs
called nucleoside analog drugs, which have been used to treat HIV, hepatitis B, and pancreatic cancer.
Not exact matches
Assembling mRNA using pseudouridine, a
nucleoside variant that occurs naturally in the body, greatly reduced the tendency of immune sentinels
called dendritic cells to shoot out inflammatory molecules in response, they reported in 2005.
Initially operating in «stealth mode» — without announcement of its existence — Moderna's team screened mRNA assembled from various modified
nucleosides and hit on one
called 1 - methylpseudouridine.
Selectivity of the therapeutic approach is achieved by producing an enzyme
called E. coli purine
nucleoside phosphorylase (PNP) directly within tumor cells and using the enzyme to generate novel chemotherapy in the tumor mass itself.
Specifically, they want their child to undergo
nucleoside bypass therapy, a treatment that Cohen
called «highly experimental» and which he noted would not work on all mitochondrial diseases.