In response to fatty deposits on the walls of the arteries, a type of
phagocyte called a macrophage identifies the growing lesions as trouble spots and infiltrates them, swelling and destabilizing the deposits.
A team of researchers led by Hongkang Xi and Menno van Lookeren Campagne, of the Department of Immunology at Genentech, Inc., in South San Francisco, Calif., discovered that a pro-inflammatory signaling protein, or cytokine,
called IL - 33, plays a key role in recruiting
phagocytes to damaged retina and inducing retinal degeneration.