The scientists then reversed this process and the synthetic liquid organelles reformed by adding another type of enzyme,
called a phosphatase, which removed the phosphate group from the peptides, reestablishing their positive charge.
By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene
called phosphatase and tensin homolog (PTEN).
Perlmann discovered that enzymes
called phosphatases can remove the phosphate from egg albumin protein.
Ovaa and Neefjes» team decided to look at another class of proteins,
called phosphatases, that act in the opposite way from kinases to see if inhibiting them would have a similar effect.
Not exact matches
The drug works by inhibiting an enzyme
called low molecular weight protein tyrosine
phosphatase (LMPTP), which seems to contribute to cells losing their sensitivity to insulin.
It is an enzyme — one in a «superfamily» of 105
called protein tyrosine
phosphatases (PTPs)-- that perform the essential biochemical task of removing phosphate groups from amino acids
called tyrosines in other proteins.
A mutation in one of the genes that controls this pathway, PTEN (also known as
phosphatase and tensin homolog), can cause a particular form of autism
called macrocephaly / autism syndrome.
In a paper published by Scientific Reports today, the research team found the activity of this protein,
called PTEN (for
Phosphatase and tensin homolog deleted on chromosome 10), is different between men and women.
The researchers also determined that SMEK1 doesn't act alone: it works in concert with Protein
Phosphatase 4 to suppress the activity of a third protein
called PAR3 that discourages neurogenesis, or the birth of new neurons.
Navire Pharma is a new company aimed at developing novel small - molecule inhibitors of a tyrosine - protein
phosphatase called SHP2 (also known as PTPN11) for genetically - driven and treatment - resistant cancer.
The University of Texas MD Anderson Cancer Center and BridgeBio Pharma today announced the launch of Navire Pharma, a biopharmaceutical company aimed at developing novel small - molecule inhibitors of a tyrosine - protein
phosphatase called SHP2 for genetically driven and treatment - resistant cancer.
Higher levels of IAP: Type Os also possess a higher amount of an enzyme
called intestinal alkaline
phosphatase, or IAP.
While research in this area is still in the preliminary stage and remains mixed in terms of results, vanadium may help to increase our body's sensitivity to insulin by inhibiting a group of enzymes
called protein tyrosine
phosphatases.
In most dogs, a liver enzyme
called serum - alkaline
phosphatase (SAP) will be elevated in the presence of high cortisol levels.