The macula is densely packed with photoreceptor cells
called rods and cones that react to light and send electrical nerve impulses to the optic nerve and into the brain.
Retinitis pigmentosa is an inherited retinal degenerative disease that causes slow but progressive vision loss due to a gradual loss of the light - sensitive retinal cells
called rods and cones.
Not exact matches
After a decade of study, biochemist James Hurley at the University of Washington in Seattle
and his colleagues have now shown that the retina's
rods and cones burn the glucose, convert leftovers into a fuel
called lactate,
and then feed that back to the RPE.
A healthy retina usually features light - sensitive cells — photoreceptors —
called cones and rods.
Genetic defects cause photoreceptor degeneration, which are majorly classified into
rod -
cone dystrophy
called retinitis pigmentosa (
rods initially degenerate, followed by
cone degeneration),
cone -
rod dystrophy (
cone degeneration, followed by
rod degeneration),
and Leber congenital amaurosis (LCA).
Rod and cone cells in the human retina contain proteins
called opsins that change shape when light strikes them.
Behind the photoreceptors is another layer of cells
called retinal pigment epithelium (RPE), which support the
rods and cones by delivering nutrients from the bloodstream
and removing waste that the
rods and cones generate.
Thanks to years of dedicated work by researchers in the laboratories of Dr. Greg Acland
and Dr. Gus Aguirre,
and aided by early support from Morris Animal Foundation
and the Collie Health Foundation, the mutation responsible for the collie PRA
called rod cone dysplasia type 2 (rcd2) has been identified.
The retinal cells that help us see in bright light are
called cones,
and these are not destroyed by the disease itself, but by the toxic by - products released by the
rod cells as they die.
Miniature
and Toy Poodles, American
and English Cocker Spaniels, Portuguese Water Dogs,
and Labrador Retrievers have a form of PRA
called progressive
rod -
cone degeneration (prcd).